Featured Research

from universities, journals, and other organizations

UCSB Lab Discovers Cross-Protective Vaccine

Date:
December 6, 2001
Source:
University Of California - Santa Barbara
Summary:
New medical research at the University of California, Santa Barbara represents a significant step toward preventing infections through the development of vaccines that elicit protection against several different disease-causing strains.

(Santa Barbara, Calif.) – New medical research at the University of California, Santa Barbara represents a significant step toward preventing infections through the development of vaccines that elicit protection against several different disease-causing strains. The work, by UCSB biologists Douglas M. Heithoff, Steve Julio, David A. Low, Robert L. Sinsheimer, and Michael J. Mahan, is an extension of earlier breakthrough research in which a strain of Salmonella was forced, through a new DNA technology, to "show its hand," thus allowing the organism to defend against it. The technology used in this vaccine is called DNA adenine methylase, or "Dam," and was discovered by Mahan’s team in 1999.

The new developments are described in articles in the November and December issues of the journal Infection and Immunity. "One of the main obstacles of vaccine development is that there are often many strains that can cause disease in individuals vaccinated against a single strain or a small set of strains," said Mahan. "This is the principle reason why different flu vaccines need to be administered every year, and why disease can occur in vaccinated individuals. This obstacle is a big problem for Salmonella, which has more than 2500 pathogenic strains. Using Dam technology, we have developed a Salmonella vaccine that is cross-protective to different salmonella strains."

He said that the development of cross-protective vaccines is paramount to the defense against biowarfare agents wherein pathogenic strains may have been "weaponized" by selecting for strains that overcome the immunity in vaccinated individuals. In effect, this renders many of our current vaccines obsolete.

In the December issue of Infection and Immunity, Mahan explains that "We have expanded the use of Dam technology to Yersinia pseudotuberculosis which is a very close cousin of the human plague-causing organism, Yersinia pestis. Dam mutants of Yersinia are completely disabled in their ability to cause disease. Immunized with these Dam mutants fully protects against Yersinia infection – in other words these immunized mice can’t be killed by virulent Yersinia."

Mahan noted that his research team is now exploring whether the Salmonella Dam technology can be used to induce immunity to other bacterial and viral pathogens. This work has been recently funded by a University of California BioSTAR biotechnology grant of $1 million. (BioSTAR -- Biotechnology Strategic Targets for Alliances in Research -- is a University of California-wide biotechnology matching grants program that forges partnerships among businesses, UC scientists, engineers and students.)

The UCSB research team has formed the company Remedyne, a private biotechnology company focused on developing potent immune stimulating vaccines and antimicrobial agents to treat infectious diseases in humans, companion animals and livestock. The University of California owns the patent for the Dam technology which is licensed to Remedyne. In human health research, the company is focusing on technology to combat cancer, infections of the ear, respiratory and urinary tract.


Story Source:

The above story is based on materials provided by University Of California - Santa Barbara. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Santa Barbara. "UCSB Lab Discovers Cross-Protective Vaccine." ScienceDaily. ScienceDaily, 6 December 2001. <www.sciencedaily.com/releases/2001/12/011206073031.htm>.
University Of California - Santa Barbara. (2001, December 6). UCSB Lab Discovers Cross-Protective Vaccine. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2001/12/011206073031.htm
University Of California - Santa Barbara. "UCSB Lab Discovers Cross-Protective Vaccine." ScienceDaily. www.sciencedaily.com/releases/2001/12/011206073031.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins