Featured Research

from universities, journals, and other organizations

UCSB Lab Discovers Cross-Protective Vaccine

Date:
December 6, 2001
Source:
University Of California - Santa Barbara
Summary:
New medical research at the University of California, Santa Barbara represents a significant step toward preventing infections through the development of vaccines that elicit protection against several different disease-causing strains.

(Santa Barbara, Calif.) – New medical research at the University of California, Santa Barbara represents a significant step toward preventing infections through the development of vaccines that elicit protection against several different disease-causing strains. The work, by UCSB biologists Douglas M. Heithoff, Steve Julio, David A. Low, Robert L. Sinsheimer, and Michael J. Mahan, is an extension of earlier breakthrough research in which a strain of Salmonella was forced, through a new DNA technology, to "show its hand," thus allowing the organism to defend against it. The technology used in this vaccine is called DNA adenine methylase, or "Dam," and was discovered by Mahan’s team in 1999.

Related Articles


The new developments are described in articles in the November and December issues of the journal Infection and Immunity. "One of the main obstacles of vaccine development is that there are often many strains that can cause disease in individuals vaccinated against a single strain or a small set of strains," said Mahan. "This is the principle reason why different flu vaccines need to be administered every year, and why disease can occur in vaccinated individuals. This obstacle is a big problem for Salmonella, which has more than 2500 pathogenic strains. Using Dam technology, we have developed a Salmonella vaccine that is cross-protective to different salmonella strains."

He said that the development of cross-protective vaccines is paramount to the defense against biowarfare agents wherein pathogenic strains may have been "weaponized" by selecting for strains that overcome the immunity in vaccinated individuals. In effect, this renders many of our current vaccines obsolete.

In the December issue of Infection and Immunity, Mahan explains that "We have expanded the use of Dam technology to Yersinia pseudotuberculosis which is a very close cousin of the human plague-causing organism, Yersinia pestis. Dam mutants of Yersinia are completely disabled in their ability to cause disease. Immunized with these Dam mutants fully protects against Yersinia infection – in other words these immunized mice can’t be killed by virulent Yersinia."

Mahan noted that his research team is now exploring whether the Salmonella Dam technology can be used to induce immunity to other bacterial and viral pathogens. This work has been recently funded by a University of California BioSTAR biotechnology grant of $1 million. (BioSTAR -- Biotechnology Strategic Targets for Alliances in Research -- is a University of California-wide biotechnology matching grants program that forges partnerships among businesses, UC scientists, engineers and students.)

The UCSB research team has formed the company Remedyne, a private biotechnology company focused on developing potent immune stimulating vaccines and antimicrobial agents to treat infectious diseases in humans, companion animals and livestock. The University of California owns the patent for the Dam technology which is licensed to Remedyne. In human health research, the company is focusing on technology to combat cancer, infections of the ear, respiratory and urinary tract.


Story Source:

The above story is based on materials provided by University Of California - Santa Barbara. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Santa Barbara. "UCSB Lab Discovers Cross-Protective Vaccine." ScienceDaily. ScienceDaily, 6 December 2001. <www.sciencedaily.com/releases/2001/12/011206073031.htm>.
University Of California - Santa Barbara. (2001, December 6). UCSB Lab Discovers Cross-Protective Vaccine. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2001/12/011206073031.htm
University Of California - Santa Barbara. "UCSB Lab Discovers Cross-Protective Vaccine." ScienceDaily. www.sciencedaily.com/releases/2001/12/011206073031.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins