Featured Research

from universities, journals, and other organizations

Study Shows Promising Results In Using Gene Modification To Deliver Interleukin 12 Directly Into Resistant Type Of Brain Tumor

Date:
December 28, 2001
Source:
Cedars-Sinai Medical Center
Summary:
In an article appearing in the Dec. 28, 2001, issue of Cancer Gene Therapy, physicians and scientists at Cedars-Sinai’s Maxine Dunitz Neurosurgical Institute describe an approach that "significantly prolonged" survival in mice with glioma – an extremely deadly type of brain cancer that is highly resistant to treatment.

LOS ANGELES (FRIDAY, DEC. 28, 2001) – The administration of Interleukin 12 (IL-12) has been shown in previous animal studies to be an effective therapy in treating cancer. But while this cytokine plays a key role in enabling the immune system’s T-cells to attack cancer cells, systemic administration can cause harmful changes in blood and tissues, and other life-threatening side effects.

Related Articles


To take advantage of IL-12’s benefits without risking the negative consequences, researchers seek IL-12 delivery methods that will attack cancer cells at the site of a tumor.

In an article appearing in the Dec. 28, 2001, issue of Cancer Gene Therapy, physicians and scientists at Cedars-Sinai’s Maxine Dunitz Neurosurgical Institute describe an approach that "significantly prolonged" survival in mice with glioma – an extremely deadly type of brain cancer that is highly resistant to treatment.

In the study, IL-12 was attached to an adenovirus and administered directly into tumors of the right corpus striatum of the brain. Mice receiving the genetically modified virus survived longer than those that received an adenovirus alone and those that were given normal saline solution. According to the paper’s senior author, John S. Yu, M.D., IL-12 also improved the immune system’s ability to infiltrate and kill tumor cells.

"Interleukin 12 is known to enhance T-helper type 1 anti-tumor immune responses," said Dr. Yu. "In our study, survival was significantly prolonged in mice that received IL-12, we had laboratory evidence of robust CD4 and CD8 T-cell infiltration of tumors, and glioma-infiltrating T lymphocytes demonstrated increased tumor-killing ability. We postulate that these findings are the result of localized induction of tumor immunity."

The study was supported in part by National Institutes of Health grant NS02232. It was conducted by researchers affiliated with Cedars-Sinai’s Maxine Dunitz Neurosurgical Institute, the medical center’s Department of Neurological Surgery, the University of California at Los Angeles, and the Department of Molecular Biology and Biochemistry at the University of California at Irvine.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Study Shows Promising Results In Using Gene Modification To Deliver Interleukin 12 Directly Into Resistant Type Of Brain Tumor." ScienceDaily. ScienceDaily, 28 December 2001. <www.sciencedaily.com/releases/2001/12/011228081300.htm>.
Cedars-Sinai Medical Center. (2001, December 28). Study Shows Promising Results In Using Gene Modification To Deliver Interleukin 12 Directly Into Resistant Type Of Brain Tumor. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2001/12/011228081300.htm
Cedars-Sinai Medical Center. "Study Shows Promising Results In Using Gene Modification To Deliver Interleukin 12 Directly Into Resistant Type Of Brain Tumor." ScienceDaily. www.sciencedaily.com/releases/2001/12/011228081300.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins