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Hebrew University And Ben-Gurion Researchers Find That Stress Causes Shift In Gene Products

Date:
January 21, 2002
Source:
Hebrew University Of Jerusalem
Summary:
Researchers at The Hebrew University of Jerusalem’s Roland Center for Neurodegenerative Diseases and at Ben-Gurion University, in work on experimental mice, have now found evidence for the fact that stress causes a shift in gene products (mRNAs) by altered splicing, the normal cut and paste mechanism that modifies mRNA.

Jerusalem, January 16, 2002 – We all know that traumatic experiences may be followed by long periods of nervousness and over-sensitive responses to signals that would not otherwise raise a response. What we do not know is how that happens, how experience translates into neurological changes that persist even after a considerable lapse of time. Researchers at The Hebrew University of Jerusalem’s Roland Center for Neurodegenerative Diseases and at Ben-Gurion University, in work on experimental mice, have now found evidence, which will be published on January 18 in the prestigious American journal Science, for the fact that stress causes a shift in gene products (mRNAs) by altered splicing, the normal cut and paste mechanism that modifies mRNA. Key features of the brain are extremely elaborate networks of nerve cells (neurons), connected through long, branched extensions that reach out to neighboring neurons. Structures (synapses) found at the ends of these extensions, are the connections between neurons of the same network. mRNAs transmit the information from genes to the apparatus in which proteins are made, so altered splicing results in different proteins being made. Stress causes changes in the splicing of many gene products, particularly in neurons, which has the result of modifying key neuronal proteins. In particular, the ACHE gene, whose protein product, acetylcholinesterase, helps control signaling across synapses between one neuron and another, produces a normally rare mRNA following trauma.


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The above story is based on materials provided by Hebrew University Of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

Hebrew University Of Jerusalem. "Hebrew University And Ben-Gurion Researchers Find That Stress Causes Shift In Gene Products." ScienceDaily. ScienceDaily, 21 January 2002. <www.sciencedaily.com/releases/2002/01/020118075319.htm>.
Hebrew University Of Jerusalem. (2002, January 21). Hebrew University And Ben-Gurion Researchers Find That Stress Causes Shift In Gene Products. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2002/01/020118075319.htm
Hebrew University Of Jerusalem. "Hebrew University And Ben-Gurion Researchers Find That Stress Causes Shift In Gene Products." ScienceDaily. www.sciencedaily.com/releases/2002/01/020118075319.htm (accessed April 20, 2014).

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