Featured Research

from universities, journals, and other organizations

Gene Therapy Promising For Rheumatoid Arthritis

Date:
February 14, 2002
Source:
Northwestern University
Summary:
Northwestern University researchers have reported the first successful use of interleukin-13 (IL-13) cytokine gene therapy to treat and prevent rheumatoid arthritis in an animal model.

Northwestern University researchers have reported the first successful use of interleukin-13 (IL-13) cytokine gene therapy to treat and prevent rheumatoid arthritis in an animal model.

Arthritis researchers James M. Woods, M.D., research assistant professor of medicine, and Alisa Koch, M.D., professor of medicine, Northwestern University Medical School, described the new gene therapy in an article in the Feb. 10 issue of the journal Human Gene Therapy.

IL-13 reduces the production of inflammatory cytokines, such as tumor necrosis factor, that are involved in joint inflammation. Previous studies have shown that levels of IL-13 are low in the joints of rats with arthritis, as well as in the human rheumatoid joint. It is therefore believed that in rheumatoid arthritis, production of inflammatory cytokines is improperly regulated. In their study, which was funded by the Arthritis Foundation, the Northwestern researchers developed a virus that contains the IL-13 gene. When the virus was injected into the joints of a rat model of arthritis, IL-13 was produced, resulting in the suppression of joint inflammation.

In addition, injection of the gene into normal rat joints prevented the development of arthritis.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "Gene Therapy Promising For Rheumatoid Arthritis." ScienceDaily. ScienceDaily, 14 February 2002. <www.sciencedaily.com/releases/2002/02/020213074724.htm>.
Northwestern University. (2002, February 14). Gene Therapy Promising For Rheumatoid Arthritis. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2002/02/020213074724.htm
Northwestern University. "Gene Therapy Promising For Rheumatoid Arthritis." ScienceDaily. www.sciencedaily.com/releases/2002/02/020213074724.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins