Featured Research

from universities, journals, and other organizations

Gene Therapy Promising For Rheumatoid Arthritis

Date:
February 14, 2002
Source:
Northwestern University
Summary:
Northwestern University researchers have reported the first successful use of interleukin-13 (IL-13) cytokine gene therapy to treat and prevent rheumatoid arthritis in an animal model.

Northwestern University researchers have reported the first successful use of interleukin-13 (IL-13) cytokine gene therapy to treat and prevent rheumatoid arthritis in an animal model.

Related Articles


Arthritis researchers James M. Woods, M.D., research assistant professor of medicine, and Alisa Koch, M.D., professor of medicine, Northwestern University Medical School, described the new gene therapy in an article in the Feb. 10 issue of the journal Human Gene Therapy.

IL-13 reduces the production of inflammatory cytokines, such as tumor necrosis factor, that are involved in joint inflammation. Previous studies have shown that levels of IL-13 are low in the joints of rats with arthritis, as well as in the human rheumatoid joint. It is therefore believed that in rheumatoid arthritis, production of inflammatory cytokines is improperly regulated. In their study, which was funded by the Arthritis Foundation, the Northwestern researchers developed a virus that contains the IL-13 gene. When the virus was injected into the joints of a rat model of arthritis, IL-13 was produced, resulting in the suppression of joint inflammation.

In addition, injection of the gene into normal rat joints prevented the development of arthritis.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "Gene Therapy Promising For Rheumatoid Arthritis." ScienceDaily. ScienceDaily, 14 February 2002. <www.sciencedaily.com/releases/2002/02/020213074724.htm>.
Northwestern University. (2002, February 14). Gene Therapy Promising For Rheumatoid Arthritis. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2002/02/020213074724.htm
Northwestern University. "Gene Therapy Promising For Rheumatoid Arthritis." ScienceDaily. www.sciencedaily.com/releases/2002/02/020213074724.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Humanoid Robot Can Recognise and Interact With People

Humanoid Robot Can Recognise and Interact With People

Reuters - Innovations Video Online (Apr. 20, 2015) An ultra-realistic humanoid robot called &apos;Han&apos; recognises and interprets people&apos;s facial expressions and can even hold simple conversations. Developers Hanson Robotics hope androids like Han could have uses in hospitality and health care industries where face-to-face communication is vital. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Labour Party Warns Britain's Health Service 'on Life Support'

Labour Party Warns Britain's Health Service 'on Life Support'

AFP (Apr. 20, 2015) Britain&apos;s opposition Labour Party Monday claimed the National Health Service (NHS) was &apos;on life support&apos; as it turned its attention to the state-run service, which is a key issue for the UK&apos;s May 7 general election. Video provided by AFP
Powered by NewsLook.com
Sierra Leone Students Back to School After Long Ebola Closure

Sierra Leone Students Back to School After Long Ebola Closure

Reuters - News Video Online (Apr. 20, 2015) After an eight-month break, children in Sierra Leone return to school for the first time since the beginning of the Ebola outbreak. Nathan Frandino reports. Video provided by Reuters
Powered by NewsLook.com
Teen E-Cigarette Use Triples, Government Debates Regulations

Teen E-Cigarette Use Triples, Government Debates Regulations

Newsy (Apr. 19, 2015) The Centers for Disease Control and Prevention says in 2014, 13.4 percent of high school students reported smoking an e-cigarette within 30 days. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins