Featured Research

from universities, journals, and other organizations

Dietary Soy Reduces Pain, Inflammation In Rats

Date:
March 15, 2002
Source:
Johns Hopkins Medical Institutions
Summary:
A diet rich in soy appears to decrease inflammation-induced pain in rats, according to a study by Johns Hopkins researchers. The research, to be presented March 15 at the annual meeting of the American Pain Society in Baltimore, shows that rats with chronic pain resulting from inflammation – similar to the pain experienced by some cancer patients – were more tolerant of painful heat stimuli and had less swelling of the inflamed region when fed a diet based on soy protein.

A diet rich in soy appears to decrease inflammation-induced pain in rats, according to a study by Johns Hopkins researchers.

Related Articles


The research, to be presented March 15 at the annual meeting of the American Pain Society in Baltimore, shows that rats with chronic pain resulting from inflammation – similar to the pain experienced by some cancer patients – were more tolerant of painful heat stimuli and had less swelling of the inflamed region when fed a diet based on soy protein.

More than two-thirds of patients with advanced cancer suffer from chronic pain. Managing this is a complex issue for physicians, who struggle to find both the nature of the pain and the most effective treatments. The causes can be a combination of pain resulting from tissue infiltration and inflammation, and neuropathic pain from tumors creeping into a nerve bed. Additionally, when cancer cells spread to bone, they may release chemicals that trigger a painful response. The most effective medications to date have been opioids such as morphine, but the side effects like constipation are so severe that not all patients can tolerate them.

"Our generation is very open to the idea of dietary methods of pain control," says Jill M. Tall, Ph.D., lead author of the study and a research fellow at Hopkins. "We hope to find complementary and alternative treatments to help people suffering from pain."

Researchers studied two groups of 10 rats. For two weeks, the first group consumed a diet based on casein protein (a milk protein found in cheese) while the second group ate a soy protein diet. At random, researchers injected either a placebo or a solution designed to induce inflammatory pain to one of the rats' hind paws.

Paw thickness was measured to assess fluid build-up. Pain tolerance was measured by assessing how long the rats could tolerate a painful heat stimulus before withdrawing the inflamed paw, and how they reacted to varying pressures applied to the paw with a series of nylon filaments. Tests were performed prior to injection and repeated six, 24, 48 and 96 hours after the injection.

Rats on the soy protein diet had significantly less swelling in their paws and a higher tolerance to heat than the casein-fed animals. Diet did not affect the rats' reaction to pressure stimuli. These results are consistent with previous research showing consumption of a soy-containing diet suppressed the development of pain following nerve injury.*1

Further studies will determine if a soy diet can reduce the opioid dosage necessary for treating chronic pain and, therefore, side effects related to the medication.

###

The study was funded by the National Center for Complementary and Alternative Medicine, part of the National Institutes of Health. Srinivasa N. Raja, M.D., Hopkins' director of pain research, was the co-author.

Poster # 777: Tall, J.M. and S.N. Raja, "Inflammatory pain induced by complete Freund's adjuvant in rats is suppressed by dietary soy."

1* Shir, M.D., Raja, S.N., Weissman, C.S., Campbell, J.N. and D.M.D. Ze'ev Seltzer, "Consumption of soy diet before nerve injury pre-empts the development of neuropathic pain in rats," Anesthesiology (2001) 95: 1238-1244.

Related Links: An image is available at: http://www.hopkinsmedicine.org/press/2002/MARCH/soyrat.htm

Johns Hopkins Division of Anesthesiology and Critical Care Medicine: http://www.hopkinsmedicine.org/anesthesiology

Johns Hopkins Center for Complementary and Alternative Medicine: http://www.hopkinsmedicine.org/cam

American Pain Society: http://www.ampainsoc.org

National Center for Complementary and Alternative Medicine: http://nccam.nih.gov


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Dietary Soy Reduces Pain, Inflammation In Rats." ScienceDaily. ScienceDaily, 15 March 2002. <www.sciencedaily.com/releases/2002/03/020315071256.htm>.
Johns Hopkins Medical Institutions. (2002, March 15). Dietary Soy Reduces Pain, Inflammation In Rats. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2002/03/020315071256.htm
Johns Hopkins Medical Institutions. "Dietary Soy Reduces Pain, Inflammation In Rats." ScienceDaily. www.sciencedaily.com/releases/2002/03/020315071256.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins