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Retinal Cell Implantation Shows Promise And Improvement In Advanced Parkinson's Disease Patients

Date:
April 18, 2002
Source:
Emory University Health Sciences Center
Summary:
An innovative procedure, in which retinal cells are implanted in the brains of patients with advanced Parkinson’s disease (PD), is showing promise, according to a group of Emory University researchers.

An innovative procedure, in which retinal cells are implanted in the brains of patients with advanced Parkinson’s disease (PD), is showing promise, according to a group of Emory University researchers. In a one-year follow-up report to be given at the American Academy of Neurology 54th Annual Meeting in Denver, Colo., on April 17, Ray Watts, M.D., professor of neurology, Emory University School of Medicine, says patients involved in this study have improved nearly 50 percent in motor function after 12 months. Dr. Watts will lead the discussion on the safety and efficacy of this pilot study at the meeting.

In this Phase I trial, Dr. Watts and colleagues implanted retinal pigment epithelial (RPE) cells attached to gelatin microcarriers into the brains of six patients with advanced PD. RPE cells, normally found in the back of the eye, are cultured in the laboratory to produce cells for this treatment. These cells provide a source of increased dopamine production.

Dopamine is a neurotransmitter produced by neurons in the brain that is found in steadily decreasing amounts as the disease progresses. The implanted retinal cells serve as a new source of dopamine production in these patients.

"This is the first human intracerebral retinal cell implantation study in the world and we are encouraged by the results so far," Dr. Watts reports. "We’ve been following these six participants for over a year, and we’ve found they’ve improved, on average, nearly 50 percent in motor function."

Improvement is being seen in their tremor, stiffness, slow movement and balance, the most common motor functions affected by Parkinson’s disease. Half of the participants are also showing improvement of dyskinesia, which are involuntary movements that are a result of medications.

The epithelial cells used in the trial were taken from a human donor. Hundreds of millions of cells were grown in cell culture from the donor cells, and they were attached to tiny gelatin beads (or microcarriers) prior to implantation. Surgeons then implanted approximately 325,000 cells in each participant during MRI-guided stereotaxic surgery. The cells were implanted in five different areas of the striatum, the part of the brain that controls movement. The cells then live on the gelatin beads in the striatum and continually provide a source of increased dopamine production. The novel cell product is called Spheramineฎ, developed by Titan Pharmaceuticals, Inc. and uses Titan’s cell-coated microcarrier (CCM‘) technology.

Participants in the Emory study only had cells implanted on one side of the brain, focusing on the side that was most affected by the disease. This implantation procedure is still investigational and has not been approved by the Food and Drug Administration (FDA) for general use.

Researchers say because it is performed stereotaxically with a needle, there is less risk of infection or bleeding. Participants did not have to take immune suppressant drugs, because the brain is relatively immune protected and these cells appear to have low tendency to produce an immune response when implanted with this microcarrier technique.

The research for this Phase I, open-label trial was supported by a grant from Titan Pharmaceuticals, Inc. and the National Institute of Neurological Disorders and Stroke (NINDS), a division of the National Institutes of Health (NIH).

"This new cell implantation therapy appears to be safe and well tolerated in participants 12 to 15 months following implantation," says Dr. Watts. "We will continue to follow these six participants for months to come. We hope to begin a Phase II controlled trial soon implanting Spheramine on both sides of the brain, instead of just one side."

Parkinson’s disease is a progressive disorder of the central nervous system affecting over one million people in the United States.


Story Source:

The above story is based on materials provided by Emory University Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

Emory University Health Sciences Center. "Retinal Cell Implantation Shows Promise And Improvement In Advanced Parkinson's Disease Patients." ScienceDaily. ScienceDaily, 18 April 2002. <www.sciencedaily.com/releases/2002/04/020418073536.htm>.
Emory University Health Sciences Center. (2002, April 18). Retinal Cell Implantation Shows Promise And Improvement In Advanced Parkinson's Disease Patients. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2002/04/020418073536.htm
Emory University Health Sciences Center. "Retinal Cell Implantation Shows Promise And Improvement In Advanced Parkinson's Disease Patients." ScienceDaily. www.sciencedaily.com/releases/2002/04/020418073536.htm (accessed October 20, 2014).

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