Featured Research

from universities, journals, and other organizations

Molecular "Motor" Drives Rotavirus Replication

Date:
May 20, 2002
Source:
Baylor College Of Medicine
Summary:
A non-structural protein called NSP2 appears to be the molecular “motor” that drives replication of rotavirus within cells lining the gastrointestinal tract -- a finding that could enable development of drugs to fight the virus, the major cause of life-threatening diarrhea in infants worldwide, said Baylor College of Medicine researchers.

HOUSTON -- (May 16, 2002) -- A non-structural protein called NSP2 appears to be the molecular “motor” that drives replication of rotavirus within cells lining the gastrointestinal tract -- a finding that could enable development of drugs to fight the virus, the major cause of life-threatening diarrhea in infants worldwide, said Baylor College of Medicine researchers.

In the May 16 issue of the journal Nature, Baylor's Dr. B.V. Venkataram Prasad and graduate student Hariharan Jayaram and their collaborators for the first time described the atomic structure of this protein that may provide some mechanistic insights into how it either drives viral genome replication or packaging during the assembly of the new viral particles within the cell.

Identifying these kinds of targets that can be used in developing anti-viral drugs may become particularly important in rotavirus since the first vaccine against rotavirus was pulled from the market in late 1999, said Prasad, a professor in the department of biochemistry and molecular biology.

Proteins similar to NSP2 exist in all kinds of double-stranded RNA viruses. They are perhaps the central piece around which the replication machinery of the virus is constructed. That machinery makes one strand of RNA, which provides a template to make a matching strand resulting in the production of the double-strand that contains the virus’ genetic code, he said. That enables the virus to produce many copies of itself that can go on to infect more cells and eventually cause diarrhea. Interfering with the action of a protein like NSP2 could stop the virus in its tracks, said Prasad.

Prasad and Jayaram, of Baylor's program in structural and computational biology and molecular physics, collaborated with Dr. Zenobia Taraporewala and Dr. John T. Patton, of the National Institute of Allergy and Infectious Diseases, on the project.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Molecular "Motor" Drives Rotavirus Replication." ScienceDaily. ScienceDaily, 20 May 2002. <www.sciencedaily.com/releases/2002/05/020516081932.htm>.
Baylor College Of Medicine. (2002, May 20). Molecular "Motor" Drives Rotavirus Replication. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2002/05/020516081932.htm
Baylor College Of Medicine. "Molecular "Motor" Drives Rotavirus Replication." ScienceDaily. www.sciencedaily.com/releases/2002/05/020516081932.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins