Featured Research

from universities, journals, and other organizations

Molecular "Motor" Drives Rotavirus Replication

Date:
May 20, 2002
Source:
Baylor College Of Medicine
Summary:
A non-structural protein called NSP2 appears to be the molecular “motor” that drives replication of rotavirus within cells lining the gastrointestinal tract -- a finding that could enable development of drugs to fight the virus, the major cause of life-threatening diarrhea in infants worldwide, said Baylor College of Medicine researchers.

HOUSTON -- (May 16, 2002) -- A non-structural protein called NSP2 appears to be the molecular “motor” that drives replication of rotavirus within cells lining the gastrointestinal tract -- a finding that could enable development of drugs to fight the virus, the major cause of life-threatening diarrhea in infants worldwide, said Baylor College of Medicine researchers.

Related Articles


In the May 16 issue of the journal Nature, Baylor's Dr. B.V. Venkataram Prasad and graduate student Hariharan Jayaram and their collaborators for the first time described the atomic structure of this protein that may provide some mechanistic insights into how it either drives viral genome replication or packaging during the assembly of the new viral particles within the cell.

Identifying these kinds of targets that can be used in developing anti-viral drugs may become particularly important in rotavirus since the first vaccine against rotavirus was pulled from the market in late 1999, said Prasad, a professor in the department of biochemistry and molecular biology.

Proteins similar to NSP2 exist in all kinds of double-stranded RNA viruses. They are perhaps the central piece around which the replication machinery of the virus is constructed. That machinery makes one strand of RNA, which provides a template to make a matching strand resulting in the production of the double-strand that contains the virus’ genetic code, he said. That enables the virus to produce many copies of itself that can go on to infect more cells and eventually cause diarrhea. Interfering with the action of a protein like NSP2 could stop the virus in its tracks, said Prasad.

Prasad and Jayaram, of Baylor's program in structural and computational biology and molecular physics, collaborated with Dr. Zenobia Taraporewala and Dr. John T. Patton, of the National Institute of Allergy and Infectious Diseases, on the project.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Molecular "Motor" Drives Rotavirus Replication." ScienceDaily. ScienceDaily, 20 May 2002. <www.sciencedaily.com/releases/2002/05/020516081932.htm>.
Baylor College Of Medicine. (2002, May 20). Molecular "Motor" Drives Rotavirus Replication. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2002/05/020516081932.htm
Baylor College Of Medicine. "Molecular "Motor" Drives Rotavirus Replication." ScienceDaily. www.sciencedaily.com/releases/2002/05/020516081932.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins