Featured Research

from universities, journals, and other organizations

Anemia Complicates Heart Failure, Should Be New Focus, Doctor Says

Date:
June 6, 2002
Source:
University Of North Carolina At Chapel Hill
Summary:
Anemia, a condition arising when the blood contains too few red cells and hence not enough of the oxygen-carrying pigment known as hemoglobin, appears to be an under-appreciated contributor to problems associated with congestive heart failure (CHF), a University of North Carolina at Chapel Hill cardiologist says. That's important, he says, because an estimated 25 percent of all Americans over age 40 will develop heart failure before they die.

CHAPEL HILL -- Anemia, a condition arising when the blood contains too few red cells and hence not enough of the oxygen-carrying pigment known as hemoglobin, appears to be an under-appreciated contributor to problems associated with congestive heart failure (CHF), a University of North Carolina at Chapel Hill cardiologist says. That's important, he says, because an estimated 25 percent of all Americans over age 40 will develop heart failure before they die.

"Five million or so people have been diagnosed with, and are living with, congestive heart failure," said Dr. Kirkwood F. Adams Jr. "Because of changes in the age of our population, that number is predicted to double within a decade, and as a result, both the economic burden and the magnitude of CHF in terms of sickness and death will continue to grow. In the past, anemia has been a neglected aspect of the condition, and that needs to change if we're going to serve patients well."

Associate professor of medicine and radiology and director of the UNC Heart Failure Program, Adams prepared his remarks for delivery Thursday (June 6) at an American Medical Association briefing on anemia in New York City.

Raising hemoglobin levels through treatment with drugs that mimic erythropoietin, which boosts red cell production, might help CHF patients by improving heart function and improving their limited ability to exercise, the physician said. Researchers already have made significant progress in treating CHF in recent years, particularly with such drugs as beta-blockers.

"But up to 40 percent of patients can't take beta-blockers long-term, and so seeking additional treatments is still important," Adams said.

In people suffering from heart failure, poor blood flow contributes to systemic changes, including impaired kidney function, he said. For various reasons, patients often become anemic.

"We recognized this anemia in the past, but many physicians questioned whether it needed to be treated if it was only moderate," Adams said. "Recent studies, however, have suggested that anemia adversely affects heart function not only in dialysis patients but in CHF patients as well."

Among those studies have been clinical trials indicating that among hospitalized heart attack victims, depression of hemoglobin, even to a limited degree, was linked to increased mortality, he said.

"Then clinicians began looking at this in CHF and began finding that anemia-reduced hemoglobin was an independent predictor of adverse outcomes," Adams said.

Two recent small and preliminary studies have further shown that hemoglobin increased in patients treated with erythropoietin and that those patients' ability to exercise improved, he said. One study even suggested that the drug could cut time spent in the hospital.

UNC serves as the coordinating center for a national heart failure registry, UNITE-HF, composed of 15 academic medical centers that collect and pool patient data for study. Working with Amgen, a drug company, and registry data, Adams and colleagues have begun studying the effects of anemia on patients' physical activity and fatigue, how hormones affect anemia and quality-of-life issues.

"This focus on anemia is new, and it is definitely worth investigating because we believe it may make a difference with many congestive heart failure patients, and results so far have been encouraging," the physician said.


Story Source:

The above story is based on materials provided by University Of North Carolina At Chapel Hill. Note: Materials may be edited for content and length.


Cite This Page:

University Of North Carolina At Chapel Hill. "Anemia Complicates Heart Failure, Should Be New Focus, Doctor Says." ScienceDaily. ScienceDaily, 6 June 2002. <www.sciencedaily.com/releases/2002/06/020606073701.htm>.
University Of North Carolina At Chapel Hill. (2002, June 6). Anemia Complicates Heart Failure, Should Be New Focus, Doctor Says. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2002/06/020606073701.htm
University Of North Carolina At Chapel Hill. "Anemia Complicates Heart Failure, Should Be New Focus, Doctor Says." ScienceDaily. www.sciencedaily.com/releases/2002/06/020606073701.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins