Featured Research

from universities, journals, and other organizations

UCLA Neuroscientists First To Show That Adult Brains Turn Back Developmental Clock To Repair Damage

Date:
July 17, 2002
Source:
University Of California - Los Angeles
Summary:
A new study by UCLA neuroscientists shows for the first time that a unique pattern of cellular activity found in early brain development also triggers repairs to damaged adult brains. The findings, appearing in the July 15 edition of the peer-reviewed Journal of Neuroscience, hold implications for treating brain damage caused by stroke and other disorders.

A new study by UCLA neuroscientists shows for the first time that a unique pattern of cellular activity found in early brain development also triggers repairs to damaged adult brains. The findings, appearing in the July 15 edition of the peer-reviewed Journal of Neuroscience, hold implications for treating brain damage caused by stroke and other disorders.

Researchers in the Department of Neurology and Brain Research Institute at UCLA used rat models to show how cells in brains damaged with stroke-like lesions, caused by interruption of blood flow, develop slow synchronous activity. This activity triggers cells to sprout new connections into areas of the brain disconnected by the lesion.

"Our research shows for the first time that this activity works to trigger repairs in adult brains," said Dr. Marie-Francoise Chesselet, professor of neurology at the David Geffen School of Medicine at UCLA and study co-author. "Previously this activity has been identified as a key component of brain development."

Scientists and clinicians had recognized this pattern of activity for many years after brain injury in humans, but its function remained unknown. This new research suggests that these cellular rhythms may be signaling a repair process in the human brain after injury.

"On its own, a damaged brain has a limited ability to repair itself. Recovery is partial," said Dr. S. Thomas Carmichael, assistant professor of neurology at UCLA and study co-author. "A better understanding of how the brain recovers from injury will allow us to manipulate the repair process and to maximize recovery from brain damage caused by stroke and other disorders."

The researchers made their discovery using a model of brain injury that allowed them to isolate signals specific to the sprouting of new connections from other changes that occur because of damage. They then measured the frequency, power and synchroneity of brain activity in a model that induced sprouting and compared to another that did not. The researchers also found that blocking the brain rhythms blocked sprouting as well.

The research was supported by a Howard Hughes Medical Institute Post-Doctoral Research Fellowship for Physicians, held by Carmichael at the time of the study, and by a National Institutes of Health grant.


Story Source:

The above story is based on materials provided by University Of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Los Angeles. "UCLA Neuroscientists First To Show That Adult Brains Turn Back Developmental Clock To Repair Damage." ScienceDaily. ScienceDaily, 17 July 2002. <www.sciencedaily.com/releases/2002/07/020717080005.htm>.
University Of California - Los Angeles. (2002, July 17). UCLA Neuroscientists First To Show That Adult Brains Turn Back Developmental Clock To Repair Damage. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2002/07/020717080005.htm
University Of California - Los Angeles. "UCLA Neuroscientists First To Show That Adult Brains Turn Back Developmental Clock To Repair Damage." ScienceDaily. www.sciencedaily.com/releases/2002/07/020717080005.htm (accessed September 20, 2014).

Share This



More Mind & Brain News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Food Addiction Might Be Caused By PTSD

Food Addiction Might Be Caused By PTSD

Newsy (Sep. 18, 2014) New research shows that women who suffer from PTSD are three times more likely to develop a food addiction. Video provided by Newsy
Powered by NewsLook.com
Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins