Featured Research

from universities, journals, and other organizations

Viagra Helps Men With Heart Failure

Date:
August 7, 2002
Source:
American Heart Association
Summary:
Men with congestive heart failure and erectile dysfunction (ED) safely used sildenafil (Viagra) to improve sexual function in a study reported in Circulation: Journal of the American Heart Association.

DALLAS, Aug. 6 - Men with congestive heart failure and erectile dysfunction (ED) safely used sildenafil (Viagra) to improve sexual function in a study reported in today's rapid access issue of Circulation: Journal of the American Heart Association.

The popular medication may even make patients more likely to take their heart failure drugs, says author Edimar Alcides Bocchi, M.D., associate professor and chief of the heart failure clinics at the Sao Paulo University Medical School in Brazil.

"Heart failure patients may become noncompliant with their congestive heart failure (CHF) treatment if they feel it causes or aggravates their ED," Bocchi says. "However, our study suggests that treating the ED may make patients more motivated to take their medicines."

Sildenafil caused no harmful effects and improved exercise performance during treadmill exercise tests in 23 men with CHF (average age 50) and a history of ED, says Bocchi.

Sildenafil blocks the activity of the enzyme phosphodiesterase type 5 (PDE5), which is active in multiple tissues and cells. The effects of PDE5 inhibition include increased production of nitric oxide, which is associated with improved function of the heart and blood vessels.

The cardiovascular effects of sildenafil have created some concern that the drug might be harmful in men with CHF. But there's not enough data on the safety or potential harm of sildenafil in CHF patients.

Most of the men had moderate or severe heart failure, and each had been referred for treatment of ED. On separate days, the men underwent two exercise treadmill tests, which consisted of a six-minute walk and a maximal exercise test. About an hour before the first test, the men received either 50 milligrams of sildenafil or a placebo. On the second day, the men received the opposite treatment (sildenafil or placebo) before exercise.

Those treated with sildenafil had significantly lower blood pressure and heart rate and improvement in measures of oxygen consumption and carbon dioxide production compared with those on placebo. Total exercise time also increased significantly. A separate evaluation showed that treatment with sildenafil was associated with higher scores on a questionnaire related to erectile function.

"Frequently, CHF patients, and especially their wives, are afraid their spouses will have heart failure symptoms or even death during sexual activity," says Bocchi. "Our study shows that the benefits may outweigh harmful side effects of treatment with sildenafil. The successful treatment of ED in CHF could not only improve sexual relationships but overall quality and success of CHF treatment."

Co-authors are Guilherme Guimarγes, Ph.D.; Amilcar Mocelin, M.D.; Fernando Bacal, M.D.; Giovanni Bellotti, M.D.; and Josι Franchini Ramires, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Viagra Helps Men With Heart Failure." ScienceDaily. ScienceDaily, 7 August 2002. <www.sciencedaily.com/releases/2002/08/020807064924.htm>.
American Heart Association. (2002, August 7). Viagra Helps Men With Heart Failure. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2002/08/020807064924.htm
American Heart Association. "Viagra Helps Men With Heart Failure." ScienceDaily. www.sciencedaily.com/releases/2002/08/020807064924.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) — Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) — Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins