Featured Research

from universities, journals, and other organizations

Compound From Yeast Shows Promise In Protecting Against Anthrax

Date:
August 26, 2002
Source:
American Chemical Society
Summary:
A compound from baker's yeast, used to make bread rise, may one day help protect people against deadly anthrax infections, according to researchers. In laboratory tests, the compound, called WGP Beta Glucan, significantly increased the survival rate of mice infected with lethal anthrax spores.

BOSTON, Aug. 22 -- A compound from baker's yeast, used to make bread rise, may one day help protect people against deadly anthrax infections, according to researchers.

Related Articles


In laboratory tests, the compound, called WGP Beta Glucan, significantly increased the survival rate of mice infected with lethal anthrax spores. Researchers believe the compound can be developed into a potent drug that has a similar effect on humans. Their findings were presented today at the 224th national meeting of the American Chemical Society, the world's largest scientific society.

WGP Beta Glucan is a patented form of beta 1,3-glucan, a polysaccharide derived from the cell wall of baker's yeast and other natural sources. Beta 1,3-glucan's potential health benefits, particularly its immune-enhancing properties, have been the subject of numerous scientific studies.

The current study represents the first demonstration that a specific form of beta 1,3-glucan can enhance the immune system's ability to kill anthrax spores, and that it can do so orally, says Gary R. Ostroff, Ph.D., vice president of research and development at Biopolymer Engineering Inc., in Eagan, Minn.

The study involved 80 mice, all of which were infected with a lethal dose of deadly anthrax spores. Of the 20 that received a placebo treatment, 30 to 50 percent survived. Of the 60 mice given beta glucan, 75 to 100 percent survived, the researcher said.

Although the mechanism of the glucan compound is not completely understood, it appears to work by binding to and strengthening macrophages, immune cells that are the first line of defense against bacterial infection. As a result, the cells fight harder against infection. In the case of anthrax, the fortified macrophage cells appear to kill the bacterial spores before they have a chance to germinate and spawn the deadly toxins that can quickly overwhelm a less-protected immune system, the researcher explained.

Studies are planned to determine the level of immune system protection that glucan offers specifically against anthrax spores, Ostroff said. The compound could potentially be developed into a drug that would work synergistically with existing anthrax therapies, including vaccines and antibiotics and antibodies to the anthrax toxin, he added.

Funding for this study was provided by Biopolymer Engineering Inc.; the Defense Research Establishment Suffield, Alberta, Canada; and Biophage Pharma Inc., Montreal, Canada.

The paper on this research, CARB 99, will be presented at 1:20 p.m., Thursday, Aug. 22, at Sheraton Boston, Republic B, as part of the topic "General Contributed Papers: Biochemistry of Carbohydrates."

Gary R. Ostroff, Ph.D., is vice president of research and development and chief scientist at Biopolymer Engineering, Inc., in Eagan, Minn.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Compound From Yeast Shows Promise In Protecting Against Anthrax." ScienceDaily. ScienceDaily, 26 August 2002. <www.sciencedaily.com/releases/2002/08/020826071731.htm>.
American Chemical Society. (2002, August 26). Compound From Yeast Shows Promise In Protecting Against Anthrax. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2002/08/020826071731.htm
American Chemical Society. "Compound From Yeast Shows Promise In Protecting Against Anthrax." ScienceDaily. www.sciencedaily.com/releases/2002/08/020826071731.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins