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Study Sheds Light On Cause Of An AIDS Treatment Side Effect

Date:
September 12, 2002
Source:
NIH/National Cancer Institute
Summary:
Highly Active Antiretroviral Therapy, or HAART, is the standard of care for HIV/AIDS patients and has prolonged the lives of countless persons with the disease. HAART has been associated, however, with the emergence of lipodystrophy syndromes. In this month's issue of the journal Mitochondrion, researchers from the National Cancer Institute (NCI), the National Institute of Standards and Technology (NIST), and Purdue University, West Lafayette, Ind., report that protease inhibitors, a component of HAART, can lead to mitochondrial toxicity. The effect, seen in this test tube study, of protease inhibitors on mitochondria could help explain the biology behind lipodystrophy and also could point to possible future therapeutic approaches for the syndrome.

Highly Active Antiretroviral Therapy, or HAART, is the standard of care for HIV/AIDS patients and has prolonged the lives of countless persons with the disease. HAART has been associated, however, with the emergence of lipodystrophy syndromes. In this month's issue of the journal Mitochondrion, researchers from the National Cancer Institute (NCI), the National Institute of Standards and Technology (NIST), and Purdue University, West Lafayette, Ind., report that protease inhibitors, a component of HAART, can lead to mitochondrial toxicity. The effect, seen in this test tube study, of protease inhibitors on mitochondria could help explain the biology behind lipodystrophy and also could point to possible future therapeutic approaches for the syndrome. Lipodystrophy is a clinical condition characterized by a poor or uneven distribution of fat cells. This distribution causes large amounts of fat to be stored in inappropriate places, which can lead to lower belly obesity and a buffalo-like hump on the upper back. Lipodystrophy side effects also include diabetes and high levels of cholesterol and triglycerides. There is significant scientific debate about the precise mechanisms and metabolic pathways involved in the development of lipodystrophy.


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The above story is based on materials provided by NIH/National Cancer Institute. Note: Materials may be edited for content and length.


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NIH/National Cancer Institute. "Study Sheds Light On Cause Of An AIDS Treatment Side Effect." ScienceDaily. ScienceDaily, 12 September 2002. <www.sciencedaily.com/releases/2002/09/020912065623.htm>.
NIH/National Cancer Institute. (2002, September 12). Study Sheds Light On Cause Of An AIDS Treatment Side Effect. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2002/09/020912065623.htm
NIH/National Cancer Institute. "Study Sheds Light On Cause Of An AIDS Treatment Side Effect." ScienceDaily. www.sciencedaily.com/releases/2002/09/020912065623.htm (accessed April 20, 2014).

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