Featured Research

from universities, journals, and other organizations

Researchers Identify First Genomic Blueprint Of Cancer Preventive Compound Found In Broccoli

Date:
September 16, 2002
Source:
Johns Hopkins University Bloomberg School Of Public Health
Summary:
Using gene chip technology, researchers at the Johns Hopkins Bloomberg School of Public Health have identified the blueprint of genes and enzymes in the body that enable sulforaphane, a compound found in broccoli and other vegetables, to prevent cancer and remove toxins from cells. The discovery was made using a "gene chip" that allows researchers to monitor the complex interactions of thousands of proteins on a whole genome rather than one at time.

Using gene chip technology, researchers at the Johns Hopkins Bloomberg School of Public Health have identified the blueprint of genes and enzymes in the body that enable sulforaphane, a compound found in broccoli and other vegetables, to prevent cancer and remove toxins from cells. The discovery was made using a "gene chip" that allows researchers to monitor the complex interactions of thousands of proteins on a whole genome rather than one at time. The study is published in the September 15, 2002 issue of the journal Cancer Research, and is the first gene profiling analysis of a cancer-preventing agent using this approach. The researchers believe the findings provide a better understanding of the body's defense mechanisms and could lead to the identification of other cancer-preventing food compounds and strategies.

Related Articles


For the study, the researchers analyzed the downstream genomic targets of the transcription factor Nrf2 (Nuclear factor E2 p45-related factor 2), which scientists previously knew was activated in response to anticancer agents such as sulforaphane. The transcription factor, Nrf2, in response to cancer preventive agents, turns on genes and pathways inside the cell, whose products help in ridding the body of carcinogens.

"Carcinogens mutate the DNA in genes, which leads to cancer. Now, we know that sulforaphane present in broccoli can turn an extensive network of genes and pathways, which can annihilate a broad spectrum of carcinogens," said Shyam Biswal, PhD, assistant professor of environmental health sciences at the Johns Hopkins Bloomberg School of Public Health.

"With this study we've identified the specific genes regulated in response to a promising chemopreventive agent, which tells us how the process of cancer chemoprevention is occurring and provides us with a novel strategy for evaluating potential cancer preventive agents in future," explained Dr. Biswal.

Dr. Biswal and his colleagues studied the gene profile of small intestines of mice to identify the genes regulated by Nrf2. The researchers treated groups of mice with sulforaphane and compared the effects to control groups in which the Nrf2 gene was knocked off. "In summary, this study expands the scope of the positive, coordinated regulation of a wide variety of cellular defense proteins by Nrf2 and underscores the potential of Nrf2 activation as a strategy for achieving cancer chemoprevention," said Dr. Biswal.

"Identification of Nrf2-regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray" was written by Rajesh K. Thimmulappa, Kim H. Mai, Sorachai Srisuma, Thomas W. Kensler, Masayuki Yamamoto, and Shyam Biswal. It is published in the September 15, 2002 edition of "Cancer Research."

The study was supported by grants from the Maryland Cigarette Restitution Fund and the American Cancer Society.

Information on automatic e-mail delivery of science and medical news releases from Johns Hopkins University is available at http://www.jhu.edu/news_info/news/listserv.html.


Story Source:

The above story is based on materials provided by Johns Hopkins University Bloomberg School Of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins University Bloomberg School Of Public Health. "Researchers Identify First Genomic Blueprint Of Cancer Preventive Compound Found In Broccoli." ScienceDaily. ScienceDaily, 16 September 2002. <www.sciencedaily.com/releases/2002/09/020916062629.htm>.
Johns Hopkins University Bloomberg School Of Public Health. (2002, September 16). Researchers Identify First Genomic Blueprint Of Cancer Preventive Compound Found In Broccoli. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2002/09/020916062629.htm
Johns Hopkins University Bloomberg School Of Public Health. "Researchers Identify First Genomic Blueprint Of Cancer Preventive Compound Found In Broccoli." ScienceDaily. www.sciencedaily.com/releases/2002/09/020916062629.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins