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Chili Peppers And Inflammation: Researchers Unravel Mechanism Of Pain Sensitivity

Date:
September 30, 2002
Source:
Massachusetts General Hospital
Summary:
Scientists at Massachusetts General Hospital (MGH) have discovered a common component to the burning sensation produced by chili peppers and the pain associated with arthritis. The finding, published in the September 26 issue of Neuron, could help scientists devise new strategies to block the pain hypersensitivity associated with inflammation.

BOSTON - September 25, 2002 - Scientists at Massachusetts General Hospital (MGH) have discovered a common component to the burning sensation produced by chili peppers and the pain associated with arthritis. The finding, published in the September 26 issue of Neuron, could help scientists devise new strategies to block the pain hypersensitivity associated with inflammation.

"The receptor activated by chili peppers in the mouth and other tissues also increases in the terminals of sensory neurons in the skin after inflammation, and this contributes to pain hypersensitivity," says Clifford Woolf, MD, PhD, director of the Neural Plasticity Research Group in the Department of Anesthesia and Critical Care at MGH. A receptor is a protein that transports a chemical signal into a cell.

Woolf and lead author Ru-Rong Ji, PhD, also of the MGH Neural Plasticity Research Group, found that the increased production of the receptor following inflammation is mediated by a signal molecule called p38, located within sensory neurons. The chili pepper receptor, which is technically called TRPV1, responds to capsaicin, the chemical that is responsible for the "hot" in peppers. It also responds to actual heat and to low pH, a condition that occurs with inflammation.

"With these findings, we're starting to understand why patients with arthritis or other inflammatory conditions are likely to have increased pain and sensitivity to heat," says Woolf, who also is Richard J. Kitz Professor of Anaesthesia Research at Harvard Medical School. He and his research team were surprised to find that the activation of p38 can cause a twenty-fold increase in the amount of TRPV1 protein in the skin but not in the activity of the gene coding for TRPV1.

"This means that the chili pepper receptor is not being regulated by the gene being switched on but by more protein being produced, an unexpected form of regulation," says Ji. He also notes that their findings will open up new options for pain management. "We could use an inhibitor to p38 to block the increase in TRPV1, therefore blocking pain in patients who suffer from many diseases and conditions that involve inflammation."

Following inflammation, the activation of p38 is very precise. The scientists found that it is caused by a specific growth factor signal acting on a particular subset of pain sensory neurons. There are a variety of pain sensations that create different changes within neurons, and all of the signals that are generated have not yet been identified. Each new discovery, like the current finding by the MGH researchers, sheds light on these complex pathways and brings new treatment strategies closer.

The other members of the MGH research team are Tarek Samad, PhD, San-Xue Jin, PhD, and Raymond Schmoll, MS, all of the MGH Neural Plasticity Research Group. The study was supported by grants from the National Institutes of Health.

Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $300 million and major research centers in AIDS, cardiovascular research, cancer, cutaneous biology, transplantation biology and photomedicine.

In 1994, the MGH joined with Brigham and Women's Hospital to form Partners HealthCare System, an integrated health care delivery system comprising the two academic medical centers, specialty and community hospitals, a network of physician groups and nonacute and home health services.


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "Chili Peppers And Inflammation: Researchers Unravel Mechanism Of Pain Sensitivity." ScienceDaily. ScienceDaily, 30 September 2002. <www.sciencedaily.com/releases/2002/09/020926065416.htm>.
Massachusetts General Hospital. (2002, September 30). Chili Peppers And Inflammation: Researchers Unravel Mechanism Of Pain Sensitivity. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2002/09/020926065416.htm
Massachusetts General Hospital. "Chili Peppers And Inflammation: Researchers Unravel Mechanism Of Pain Sensitivity." ScienceDaily. www.sciencedaily.com/releases/2002/09/020926065416.htm (accessed July 31, 2014).

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