Featured Research

from universities, journals, and other organizations

Aspirin Inhibits Ovarian Cancer Growth, Lab Study Finds

Date:
November 7, 2002
Source:
University Of South Florida Health Sciences Center
Summary:
Aspirin may reduce ovarian cancer growth, a laboratory study by the USF College of Medicine has shown. The study, published in the October issue of the journal Obstetrics and Gynecology, demonstrated that aspirin inhibited ovarian tumor cell growth by as much as 68 percent. The higher the dosage of aspirin added to the culture of ovarian cancer cells, the more growth inhibition was observed.

Tampa, FL (Nov. 5, 2002) -- Aspirin may reduce ovarian cancer growth, a laboratory study by the USF College of Medicine has shown.

The study, published in the October issue of the journal Obstetrics and Gynecology, demonstrated that aspirin inhibited ovarian tumor cell growth by as much as 68 percent. The higher the dosage of aspirin added to the culture of ovarian cancer cells, the more growth inhibition was observed.

The researchers also found that combining aspirin with a monoclonal antibody specific for the HER-2/neu protein created even greater suppression of growth than treating the tumor cells with aspirin alone. This combination decreased ovarian cancer cell growth by 84 percent.

HER-2/neu is a receptor protein on the tumor cell surface that binds to a substance that stimulates growth. The protein is elevated in a third of ovarian cancers.

Jeanne Becker, PhD, an associate professor in the Department of Obstetrics and Gynecology, was senior author for the study, along with co-author Janet Drake, MD, formerly a gynecologic oncology fellow at USF. Last year, Dr. Becker's laboratory demonstrated that aspirin inhibits the growth of endometrial cancer by promoting programmed cell death, or apoptosis.

USF continues its preclinical studies to determine how aspirin inhibits tumor cell growth. Dr. Becker said much more research must be done, including patient studies, before women are urged to begin taking aspirin to stave off ovarian cancer.

Because there are few early symptoms, ovarian cancer is often diagnosed in advanced stages and kills more women than any other gynecological cancer. The American Cancer Society estimates that in 2002 nearly 14,000 women will die of ovarian cancer, and 23,300 new cases will be diagnosed.


Story Source:

The above story is based on materials provided by University Of South Florida Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of South Florida Health Sciences Center. "Aspirin Inhibits Ovarian Cancer Growth, Lab Study Finds." ScienceDaily. ScienceDaily, 7 November 2002. <www.sciencedaily.com/releases/2002/11/021107074244.htm>.
University Of South Florida Health Sciences Center. (2002, November 7). Aspirin Inhibits Ovarian Cancer Growth, Lab Study Finds. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2002/11/021107074244.htm
University Of South Florida Health Sciences Center. "Aspirin Inhibits Ovarian Cancer Growth, Lab Study Finds." ScienceDaily. www.sciencedaily.com/releases/2002/11/021107074244.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins