Featured Research

from universities, journals, and other organizations

Hormone Replacement Therapy Reduces Diabetes Rates In Some Women

Date:
January 7, 2003
Source:
University Of California - San Francisco
Summary:
Hormone replacement therapy (HRT) can reduce diabetes by 35 percent in women with coronary disease, according to a study of more than 2000 women. The authors do not recommend the use of hormones for disease prevention, but instead encourage further study of the effects of estrogen and progestin hormone therapy on metabolic complications.

Hormone replacement therapy (HRT) can reduce diabetes by 35 percent in women with coronary disease, according to a study of more than 2000 women. The authors do not recommend the use of hormones for disease prevention, but instead encourage further study of the effects of estrogen and progestin hormone therapy on metabolic complications.

Principal Investigator Alka Kanaya, MD, led a team in further analysis of data from the Heart and Estrogen/Progestin Replacement Study (HERS). HERS was a randomized, blinded trial led by UCSF to determine the effects of HRT compared with placebo in older postmenopausal women with heart disease.

"The potential benefit to patients for one health outcome needs to be weighed against the risk for others, such as coronary events and breast cancer," said Kanaya, a UCSF assistant professor of medicine. "But our data allude to important metabolic benefits of HRT that should be studied further," she said. Current clinical practice guidelines recommend the use of HRT for the short-term relief of menopausal symptoms only.

The new study, "Glycemic Effects of Postmenopausal Hormone Therapy," is published in the January 6 issue of the Annals of Internal Medicine and was funded in part by the Department of Health and Human Services.

Some of the HERS participants had existing diabetes and some began the trial with impaired fasting glucose (IFG), a condition in which the blood glucose level is elevated when measured after an overnight fast but is not high enough to be classified as diabetes. Equal proportions of women with diabetes, with IFG, and without diabetes were randomly assigned to HRT or placebo in the trial.

The diabetes researchers evaluated the effect of HRT on fasting glucose levels and on any new diagnoses of diabetes among the HERS participants over four years of follow up. All HERS participants had their fasting glucose levels measured during a baseline exam at the study's beginning, after the first year of the study, and at the study's end. Researchers found that a new diagnosis of diabetes was made during the four-year trial in a total of 160 women: 62 women assigned to hormone therapy and 98 on placebo.

The women who received placebo had an increased risk for diabetes which could not be explained by other factors such as weight and waist circumference. The placebo group -- both those with and those without diabetes at the study's beginning -- had significant worsening of their fasting glucose measures compared with the women who received HRT. The trend was similar among women with IFG.

HERS was the first randomized, blinded, placebo-controlled trial large enough to detect the effects of hormone therapy on disease outcomes. Research was conducted at outpatient and community settings at 20 United States clinical centers. A total of 2,763 postmenopausal women with coronary heart disease were enrolled in HERS.

Guidelines for the use of HRT underwent dramatic shifts during 2002, when further data from HERS and another trial, the Women's Health Initiative, demonstrated elevated risks of heart disease and breast cancer among women using post menopausal HRT.

Co-investigators of the new study are David Herrington, MD, Wake Forest University; Eric Vittinghoff, PhD, UCSF; Feng Lin, MS, UCSF; Deborah Grady, MD, MPH, UCSF; Vera Bittner, MD, MSPH, University of Alabama; Jane A. Cauley, DrPH, University of Pittsburgh; and Elizabeth Barrett-Connor, MD, University of California, San Diego.

HERS was funded by Wyeth-Ayerst.


Story Source:

The above story is based on materials provided by University Of California - San Francisco. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - San Francisco. "Hormone Replacement Therapy Reduces Diabetes Rates In Some Women." ScienceDaily. ScienceDaily, 7 January 2003. <www.sciencedaily.com/releases/2003/01/030107073433.htm>.
University Of California - San Francisco. (2003, January 7). Hormone Replacement Therapy Reduces Diabetes Rates In Some Women. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2003/01/030107073433.htm
University Of California - San Francisco. "Hormone Replacement Therapy Reduces Diabetes Rates In Some Women." ScienceDaily. www.sciencedaily.com/releases/2003/01/030107073433.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Uganda on Alert for Ebola but No Confirmed Cases

Uganda on Alert for Ebola but No Confirmed Cases

AFP (July 31, 2014) Uganda's health minister said on Thursday that there are no confirmed cases of Ebola in the country, but that it remained on alert for cases of the deadly virus. Uganda has suffered Ebola outbreaks in the past, most recently in 2012. Duration: 00:59 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins