Featured Research

from universities, journals, and other organizations

Gene Appears To Play Important Important Role In Controlling The Growth Of Colorectal Cancer Cells

Date:
February 18, 2003
Source:
University Of Pittsburgh Medical Center
Summary:
Researchers at the University of Pittsburgh Cancer Institute (UPCI), in collaboration with Johns Hopkins University School of Medicine have found that a recently discovered gene plays an essential role in mediating apoptosis, or cell death, in colorectal cancer cells.

PITTSBURGH, Feb. 17 – Researchers at the University of Pittsburgh Cancer Institute (UPCI), in collaboration with Johns Hopkins University School of Medicine have found that a recently discovered gene plays an essential role in mediating apoptosis, or cell death, in colorectal cancer cells. The results are published in the Feb. 18 issue of Proceedings of the National Academy of Sciences.

Related Articles


The gene, PUMA, or p53 up-regulated modulator of apoptosis, is controlled by p53 – a tumor-suppressing gene that prevents normal cells from turning into life-threatening tumor cells. Previous research has determined that damage to p53 is fundamental to the development of a vast majority of cancers, and inactivation of the growth-controlling function of p53 is critical to the growth and spread of most cancers.

The leading investigators of the study, Lin Zhang, Ph.D., assistant professor of pharmacology, University of Pittsburgh and Jian Yu, Ph.D., assistant professor of pathology, University of Pittsburgh, performed several gene targeting experiments involving PUMA and found that if the gene is deleted in colorectal cancer cells, cell death is prevented. These findings build on previous findings published in 2001 in Molecular Cell, where the same research team identified PUMA as a novel gene that when expressed, resulted in rapid and profound apoptosis.

"This research results from our interest in looking at how cancer cells die when treated with anti-cancer therapies and why chemotherapy often fails to destroy cancer," said Dr. Yu. "We have learned that when we get rid of PUMA in cancer cells, the cells are more resistant to dying compared to their counterparts that have intact PUMA."

"Given these findings, our next step is to look for compounds that elevate the level of PUMA in colorectal cancer cells, enabling us to test promising new therapies for cancer. PUMA itself is also an attractive target for gene therapy. At UPCI, we are trying to expand these approaches to a variety of cancers," said Dr. Zhang.

###

This study was funded, in part, by a grant from the National Institutes of Health. Co-authors of the study include, Zhenghe Wang, Ph.D., Kenneth W. Kinzler, Ph.D., and Bert Vogelstein, M.D., all with the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University.

World-renowned for innovative approaches to cancer prevention, detection and diagnosis, UPCI recently relocated to the Hillman Cancer Center at UPMC Shadyside Hospital. The Hillman Cancer Center is the flagship facility for both UPCI and the UPMC Cancer Centers – a network of more than 30 office-based medical oncology practices and regional cancer centers that provide the highest standard of care for patients throughout western Pennsylvania. UPCI and the UPMC Cancer Centers' program in cancer currently ranks 11th in the country.

For more information on this and other ongoing research projects at UPCI, please visit http://www.upci.upmc.edu .


Story Source:

The above story is based on materials provided by University Of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pittsburgh Medical Center. "Gene Appears To Play Important Important Role In Controlling The Growth Of Colorectal Cancer Cells." ScienceDaily. ScienceDaily, 18 February 2003. <www.sciencedaily.com/releases/2003/02/030218085231.htm>.
University Of Pittsburgh Medical Center. (2003, February 18). Gene Appears To Play Important Important Role In Controlling The Growth Of Colorectal Cancer Cells. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2003/02/030218085231.htm
University Of Pittsburgh Medical Center. "Gene Appears To Play Important Important Role In Controlling The Growth Of Colorectal Cancer Cells." ScienceDaily. www.sciencedaily.com/releases/2003/02/030218085231.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins