Featured Research

from universities, journals, and other organizations

Selegiline Hydrochloride May Help Smokers Quit

Date:
February 24, 2003
Source:
NIH/National Institute On Drug Abuse
Summary:
NIDA-supported researchers from Yale University Transdisciplinary Tobacco Use Research Center (TTURC) have found more evidence that monoamine oxidase-B (MAO-B) inhibitors may be an effective treatment for nicotine addiction. MAO-B is an enzyme that breaks down dopamine.

NIDA-supported researchers from Yale University Transdisciplinary Tobacco Use Research Center (TTURC) have found more evidence that monoamine oxidase-B (MAO-B) inhibitors may be an effective treatment for nicotine addiction. MAO-B is an enzyme that breaks down dopamine. The symptoms of nicotine withdrawal have been associated with a decrease in the concentration of dopamine, so increasing dopamine levels with MAO-B inhibitors may be helpful for the treatment of nicotine addiction.

Related Articles


Prior to the start of the study, researchers administered a battery of tests to volunteers to assess their dependence on nicotine and the intensity of their nicotine cravings. Those with current symptoms of major depression or alcohol or drug dependence were excluded from the study. Volunteers currently prescribed antidepressant or opioid medications were also excluded.

Forty cigarette smokers were then assigned to receive the MAO-B inhibitor, selegiline hydrochloride (SEL), or a placebo for 8 weeks. During the first 7 days, the medication was administered once per day and on day eight, it was increased to twice daily for the remainder of the study. Day 15 was designated as the smoking “quit date.” Smoking cessation counseling, which included motivational enhancement therapy and relapse prevention strategies, was provided. Each month, volunteers answered a series of standardized questionnaires to assess symptoms of depression and the intensity of their nicotine cravings. Their breath and plasma were also analyzed to verify abstinence from using tobacco. After completion of the study, medication was tapered for one week and then discontinued. Six months later, smoking abstinence rates were also determined.

After 8 weeks of treatment, 45 percent of participants receiving SEL had quit smoking tobacco compared to 15 percent of those receiving placebo. During the last 4 weeks of the study, 30 percent of participants receiving SEL reported that they had completely abstained from smoking compared to 5 percent of those receiving placebo. At the 6-month follow-up, smoking cessation rates were 20 percent for those that received SEL and 5 percent for placebo. Cravings for nicotine were not affected by SEL.

WHAT IT MEANS: These findings suggest that the MAO-B inhibitor, selegiline hydrocholoride (SEL), may be an effective treatment for nicotine addiction. Further studies of this medication for smoking cessation are needed.

###

This study was published by lead investigator Dr. Tony George in the January 15, 2003 issue of Biological Psychiatry.


Story Source:

The above story is based on materials provided by NIH/National Institute On Drug Abuse. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute On Drug Abuse. "Selegiline Hydrochloride May Help Smokers Quit." ScienceDaily. ScienceDaily, 24 February 2003. <www.sciencedaily.com/releases/2003/02/030224082051.htm>.
NIH/National Institute On Drug Abuse. (2003, February 24). Selegiline Hydrochloride May Help Smokers Quit. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2003/02/030224082051.htm
NIH/National Institute On Drug Abuse. "Selegiline Hydrochloride May Help Smokers Quit." ScienceDaily. www.sciencedaily.com/releases/2003/02/030224082051.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins