Featured Research

from universities, journals, and other organizations

WWII Discovery May Counter Bioterrorists

Date:
February 28, 2003
Source:
Indiana University
Summary:
A compound developed by British scientists early in World War II as a treatment against chemical weapons has value against today's threat of bioterrorism, according to Indiana University School of Medicine researchers at Indiana University-Purdue University Fort Wayne.

FORT WAYNE, Indiana - A compound developed by British scientists early in World War II as a treatment against chemical weapons has value against today's threat of bioterrorism, according to Indiana University School of Medicine researchers at Indiana University-Purdue University Fort Wayne.

Related Articles


Researchers studying British Anti-Lewisite provide an overview of its historical uses, development and clinical implications today of the heavy metal chelating agent, detailed in the March issue of the Annals of Emergency Medicine. BAL is a medical therapy to remove metal poisonings from the body.

"BAL was secretly developed more than six decades ago by biochemists at Oxford University and is still stocked in many hospital pharmacies and used occasionally by emergency physicians," says article co-author Joel A. Vilensky, Ph.D., professor of anatomy at the School's Fort Wayne Center for Medical Education.

Kent L. Redman, Ph.D., associate professor of biochemistry and molecular biology, co-authored the study with Dr. Vilensky.

"The possible threat of terrorism gives this World War II discovery renewed significance among emergency physicians because it is a treatment for Lewisite, a chemical warfare agent that produces immediate pain and blistering on contact and can cause blindness if it gets into the eyes," Dr. Vilensky notes. "Lewisite is a threat because it is easy for any country to manufacture with simple pesticide-manufacturing technology." Iraq is believed to have used Lewisite in its earlier war with Iran.

Developed for use during World War I, Lewisite is an arsenic-based liquid chemical compound that, similar to mustard, is easily vaporized into a poison gas and is capable of penetrating ordinary clothing and rubber. When inhaled in high concentrations, it may be fatal in as few as 10 minutes.

Fear of German use of Lewisite led British scientists at the beginning of World War II to develop an antidote, 2,3-dimercaptopropanol, which came to be known as BAL. The treatment is capable of removing heavy metals such as arsenic, copper, mercury and lead from the human body.

After the war, BAL was put to clinical use by becoming the first successful treatment for Wilson's disease, a genetic disorder that causes the body to retain copper. If not treated, Wilson's disease can cause severe brain damage, liver failure, and death. Today, BAL is one recommended treatment for children with very high blood lead levels in conjunction with other agents, the IU School of Medicine researchers noted in their article.

"Little did those Oxford biochemists working on the antidote to a greatly feared chemical warfare agent realize that BAL would still be needed 60 years later for heavy metal poisoning," Dr. Redman notes. "In the process, BAL helped change clinical medicine and perhaps altered the course of World War II by reducing the fear of Lewisite's use on the battlefield."

###

The Annals of Emergency Medicine is the journal of the American College of Emergency Physicians, an organization of 23,000 members.

The IU School of Medicine is the second largest medical school in the United States with more than 1,200 students. It has nine medical centers in Indiana for first- and second-year students, including the Fort Wayne Center for Medical Education. All medical students complete their final two years at the School's main campus in Indianapolis.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Cite This Page:

Indiana University. "WWII Discovery May Counter Bioterrorists." ScienceDaily. ScienceDaily, 28 February 2003. <www.sciencedaily.com/releases/2003/02/030228072906.htm>.
Indiana University. (2003, February 28). WWII Discovery May Counter Bioterrorists. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2003/02/030228072906.htm
Indiana University. "WWII Discovery May Counter Bioterrorists." ScienceDaily. www.sciencedaily.com/releases/2003/02/030228072906.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Hikers Rescued After Fall from Oregon Mountain

Hikers Rescued After Fall from Oregon Mountain

AP (Feb. 1, 2015) Two climbers who were hurt in a fall on Mount Hood are now being treated for their injuries. Rescue officials say they were airlifted off the mountain Saturday afternoon by an Oregon National Guard helicopter. (Feb. 2) Video provided by AP
Powered by NewsLook.com
Smart Glasses Augment Reality to Help Visually Impaired

Smart Glasses Augment Reality to Help Visually Impaired

Reuters - Innovations Video Online (Feb. 1, 2015) New augmented reality smart glasses developed by researchers at Oxford University can help people with visual impairments improve their vision by providing depth-based feedback, allowing users to "see" better. Joel Flynn reports. Video provided by Reuters
Powered by NewsLook.com
Flu Season Hitting Elderly Hard

Flu Season Hitting Elderly Hard

Reuters - US Online Video (Jan. 31, 2015) The CDC says this year&apos;s flu season is hitting people 65 years of age and older especially hard. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins