Featured Research

from universities, journals, and other organizations

Derivative Of Green Tea Leaf May Help With Metabolic Syndrome X, A Potentially Deadly Disorder

Date:
April 14, 2003
Source:
American Physiological Society
Summary:
Tegreen, a tea polyphenols product containing more than 65 percent tea catechins, is capable of improving glucose and lipid metabolism in an obese rat model, researchers report.

April 9, 2003 (San Diego, CA) -- Metabolic Syndrome X is the term used to describe a group of heart disease risk factors, including high levels of abdominal fat, bad cholesterol, high blood pressure, and abnormal glucose metabolism. The syndrome, also known as Insulin Resistance Syndrome, is thought to run in families with a history of type 2 diabetes. It is a syndrome that can kill.

Related Articles


Excessive caloric intake is thought to be one of the root causes. Consequently, physicians have prescribed weight loss, exercise and a healthy diet to combat it. A new weapon might eventually be added to the arsenal: consumption of Tegreen, a tea polyphenols product containing in excess of 65 percent tea catechins, derived from the green tea leaf. The results of a new animal model study reveal the benefits of Tegreen in improving lipid and glucose metabolisms, enhancing insulin sensitivity, and balancing the metabolic rate of fat deposit and fat burning.

The authors of a new study, "Tegreen Improves glucose and lipid metabolism in obese rats that have features similar to Metabolic Syndrome X," are Hong Yu, Zhigang Zhu and Weiti Yin, all of the Pharmanex Beijing Pharmacology Center, Beijing, China; and Jia-Shi Zhu of Pharmanex, LLC, Provo, UT. Dr. Jia-Shi Zhu will present their findings at Experimental Biology 2003, a meeting sponsored by the American Physiological Society, being held April 11-15, 2003, at the San Diego Convention Center, San Diego, CA.

Methodology

Tegreen powder, containing >97 percent tea polyphenols or >65 percent tea catechins, was used with 44 female Sprague-Dawley rats, weighing 190-210 g. A high-dose treatment was developed using Tegreen powder (0.75 g) dissolved in 100 ml of solution for a 7.5 mg/ml suspension. For a low-dose treatment, Tegreen power (0.25 g) was dissolved in solution to make a 2.5 mg/ml suspension.

The subjects were housed with a 12-hour light/dark cycle. After being acclimatized to their surroundings, they were randomly placed in one of four experimental groups. Rats in a normal diet placebo group were fed normal rat forage. The other rats were fed a high-calorie diet, including a high-calorie diet placebo, for a period of 56 days. Two treatment groups were given Tegreen at a dose of 25 or 75 mg/kg. Following fasting of ten hours, orbital blood samples were collected to examine fasting serum glucose, serum triglycerides, plasma insulin, and plasma glucagon. Glucose insulin index and ratio of insulin:Glucagon were calculated. Abdominal adipose tissue was isolated and weighted.

Results

The researchers made the following observations:

* Establishment of Metabolic Syndrome X: Rats fed the high-calorie diet significantly increased their weight of abdominal adipose tissue and ratio of Insulin:Glucagon, indicating increased adipose lipogenesis and deposit, and decreased fat burning. The glucose-insulin index was lowered by 13 percent in rats on the high calorie diet, indicating reduced insulin sensitivity or insulin resistance and excessive visceral adipose accumulation. These metabolic changes suggested that rats on the experimental diet developed Metabolism Syndrome X.

* Decreases in fasting blood glucose: After the eight-week Tegreen treatment, fasting blood glucose was decreased significantly (by 21.5 percent and 15.7 percent, respectively) in rats given Tegreen at a dose of 25 or 75 mg/kg.

* Changes in fasting plasma insulin (Ins): Fasting plasma insulin was decreased by 40.7 percent in rats given Tegreen at a dose of 25 mg/kg, and by 31.2 percent at a dose of 75 mg/kg.

* Increases in glucose-insulin index: the insulin index was increased significantly, 31.4 percent and 24.8 percent, respectively, in rats given Tegreen, suggesting enhanced insulin sensitivity by Tegreen treatment.

* Decreases in fasting serum triglycerides (TG): fasting serum TG was significantly decreased (31 percent and 54.3 percent, respectively) in rats receiving the test product.

* Decreases in the weight of abdominal adipose pad (fat) relative to body weight: Using an abdominal adipose pad index (API), measurements showed significant decreases of 11.9 percent in those consuming 25 mg/kg and 21.6 percent in those consuming 75 mg/kg, indicating decreased visceral depot fat.

* Changes in fasting plasma glucagon (Glca): Fasting plasma glucagon was increased slightly -- 13.1 percent -- at a dose of 25 mg/kg, and by 22.6 percent at 75 mg/kg.

* Decreases in ratio of insulin to glucagons (Ins/Glca): Ins/Glca was significantly decreased (49.9 percent) at a dose of 25 mg/kg, and by 43.1 at a dose of 75 mg/kg, suggesting increases in fat burning and decreases in visceral fat deposit.

Conclusions

This study reveals that oral administration of Tegreen is capable of improving glucose and lipid metabolisms in an obese rat model induced by a high-calorie diet. The close association of disordered lipid metabolism with other metabolic disturbances may be the unique feature of Metabolic Syndrome X. This study clearly shows that Tegreen intervention can significantly decrease visceral fat depot and increase the insulin's sensitivity, presumably touching one of the pathological root causes of this potentially deadly syndrome.

-end-

The American Physiological Society (APS) is one of the world's most prestigious organizations for physiological scientists. These researchers specialize in understanding the processes and functions underlying human health and disease. Founded in 1887 the Bethesda, MD-based Society has more than 10,000 members and publishes 3,800 articles in its 14 peer-reviewed journals each year.


Story Source:

The above story is based on materials provided by American Physiological Society. Note: Materials may be edited for content and length.


Cite This Page:

American Physiological Society. "Derivative Of Green Tea Leaf May Help With Metabolic Syndrome X, A Potentially Deadly Disorder." ScienceDaily. ScienceDaily, 14 April 2003. <www.sciencedaily.com/releases/2003/04/030414084647.htm>.
American Physiological Society. (2003, April 14). Derivative Of Green Tea Leaf May Help With Metabolic Syndrome X, A Potentially Deadly Disorder. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2003/04/030414084647.htm
American Physiological Society. "Derivative Of Green Tea Leaf May Help With Metabolic Syndrome X, A Potentially Deadly Disorder." ScienceDaily. www.sciencedaily.com/releases/2003/04/030414084647.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins