Featured Research

from universities, journals, and other organizations

Drug Shows Promise In Preventing Type 1 Diabetes

Date:
April 30, 2003
Source:
University Of Virginia Health System
Summary:
An anti-inflammatory drug called lisofylline, originally developed as an infection-fighter for cancer patients, could be beneficial for people at risk for Type 1 diabetes, according to researchers at the University of Virginia Health System.

CHARLOTTESVILLE, Va., April 30 – An anti-inflammatory drug called lisofylline, originally developed as an infection-fighter for cancer patients, could be beneficial for people at risk for Type 1 diabetes, according to researchers at the University of Virginia Health System.

U.Va. researchers discovered that two weeks of lisofylline (LSF) treatment reduced the incidence of Type 1 diabetes in mice to 25 percent compared to 92 percent in mice who did not receive LSF. Diabetes was induced in the mice by multiple low doses of a certain drug.

Type 1 diabetes, also known as insulin dependent diabetes mellitus, occurs when the immune system attacks beta cells in the pancreas, leaving the body unable to produce insulin. Insulin is needed by the body to process sugar, the basic fuel for cells.

"Our hope is that, one day, a clinician can use lisofylline to slow down or prevent this disease in people at high-risk for Type 1 diabetes," said Dr. Zandong Yang, an assistant professor of research in the division of endocrinology and metabolism at U.Va. "We think this drug may have the ability to protect these insulin-producing cells from death or damage. "

The research by Dr. Yang's team is published in the April 30 online issue of the journal Pancreas, found on the web at: http://www.pancreasjournal.com.

The U.Va. researchers say lisofylline protects insulin-producing cells by inhibiting the production and action of pro-inflammatory cytokines, proteins produced by immune cells that can cause cell death and dysfunction. Importantly, LSF treatment also restored insulin secretion, according to the U.Va. study.

More than 700,000 Americans suffer from Type 1 diabetes, according to the American Diabetes Association (ADA.) Most require several insulin injections a day or an insulin pump. Type 1 diabetes accounts for about five to 10 percent of all diagnosed cases of diabetes, according to the ADA. People with Type 1 diabetes are at a greater risk for heart disease, stroke, and eye and kidney diseases. Causes of Type 1 are believed to include autoimmune, genetic and environmental factors.


Story Source:

The above story is based on materials provided by University Of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University Of Virginia Health System. "Drug Shows Promise In Preventing Type 1 Diabetes." ScienceDaily. ScienceDaily, 30 April 2003. <www.sciencedaily.com/releases/2003/04/030430081525.htm>.
University Of Virginia Health System. (2003, April 30). Drug Shows Promise In Preventing Type 1 Diabetes. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2003/04/030430081525.htm
University Of Virginia Health System. "Drug Shows Promise In Preventing Type 1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2003/04/030430081525.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins