Featured Research

from universities, journals, and other organizations

Drug Shows Promise In Preventing Type 1 Diabetes

Date:
April 30, 2003
Source:
University Of Virginia Health System
Summary:
An anti-inflammatory drug called lisofylline, originally developed as an infection-fighter for cancer patients, could be beneficial for people at risk for Type 1 diabetes, according to researchers at the University of Virginia Health System.

CHARLOTTESVILLE, Va., April 30 – An anti-inflammatory drug called lisofylline, originally developed as an infection-fighter for cancer patients, could be beneficial for people at risk for Type 1 diabetes, according to researchers at the University of Virginia Health System.

Related Articles


U.Va. researchers discovered that two weeks of lisofylline (LSF) treatment reduced the incidence of Type 1 diabetes in mice to 25 percent compared to 92 percent in mice who did not receive LSF. Diabetes was induced in the mice by multiple low doses of a certain drug.

Type 1 diabetes, also known as insulin dependent diabetes mellitus, occurs when the immune system attacks beta cells in the pancreas, leaving the body unable to produce insulin. Insulin is needed by the body to process sugar, the basic fuel for cells.

"Our hope is that, one day, a clinician can use lisofylline to slow down or prevent this disease in people at high-risk for Type 1 diabetes," said Dr. Zandong Yang, an assistant professor of research in the division of endocrinology and metabolism at U.Va. "We think this drug may have the ability to protect these insulin-producing cells from death or damage. "

The research by Dr. Yang's team is published in the April 30 online issue of the journal Pancreas, found on the web at: http://www.pancreasjournal.com.

The U.Va. researchers say lisofylline protects insulin-producing cells by inhibiting the production and action of pro-inflammatory cytokines, proteins produced by immune cells that can cause cell death and dysfunction. Importantly, LSF treatment also restored insulin secretion, according to the U.Va. study.

More than 700,000 Americans suffer from Type 1 diabetes, according to the American Diabetes Association (ADA.) Most require several insulin injections a day or an insulin pump. Type 1 diabetes accounts for about five to 10 percent of all diagnosed cases of diabetes, according to the ADA. People with Type 1 diabetes are at a greater risk for heart disease, stroke, and eye and kidney diseases. Causes of Type 1 are believed to include autoimmune, genetic and environmental factors.


Story Source:

The above story is based on materials provided by University Of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University Of Virginia Health System. "Drug Shows Promise In Preventing Type 1 Diabetes." ScienceDaily. ScienceDaily, 30 April 2003. <www.sciencedaily.com/releases/2003/04/030430081525.htm>.
University Of Virginia Health System. (2003, April 30). Drug Shows Promise In Preventing Type 1 Diabetes. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2003/04/030430081525.htm
University Of Virginia Health System. "Drug Shows Promise In Preventing Type 1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2003/04/030430081525.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins