Featured Research

from universities, journals, and other organizations

Benefits of Lung Surgery Reported for Emphysema Patients

Date:
May 21, 2003
Source:
Johns Hopkins Medical Institutions
Summary:
Patients with severe emphysema who undergo lung volume reduction surgery (LVRS) along with medical management are more likely to function better and face no increased risk of death after two years compared to those treated with medical management alone, according to results of a five-year study at Johns Hopkins and 16 other clinical research centers across the country.

Patients with severe emphysema who undergo lung volume reduction surgery (LVRS) along with medical management are more likely to function better and face no increased risk of death after two years compared to those treated with medical management alone, according to results of a five-year study at Johns Hopkins and 16 other clinical research centers across the country.

The investigators also found that patients whose disease was concentrated in the upper lobes of the lungs and whose exercise capacity was low before surgery were more likely to survive longer and function better after surgery than those who received medical management alone. In contrast, patients who had more diffuse disease and greater exercise capacity were more likely to develop complications from the surgery.

"The findings provide crucial new information for weighing the benefits and risks of lung volume reduction surgery for the treatment of severe emphysema," said Steven Piantadosi, M.D., Ph.D., professor of oncology at Johns Hopkins and a lead investigator in the study.

Added Robert Wise, M.D., professor of medicine at Johns Hopkins and an author of the report, "They also tell us which patients will respond well to surgery and which ones are at risk of complications."

The researchers noted that although, on average, lung function and exercise capacity among surviving surgical patients improved significantly following LVRS, after two years these indicators returned to the same level as before surgery. In contrast, those who received medical therapy alone experienced losses in lung function to below baseline. Moreover, while the overall mortality rate was similar between the two groups throughout the study period, the risk of death during the first 90 days was significantly higher for patients who underwent surgery compared to those who received medical therapy alone (7.9 percent versus 1.3 percent).

The multicenter study, called the National Emphysema Treatment Trial (NETT), was designed to evaluate the effectiveness and safety of adding LVRS to medical management including pulmonary rehabilitation for advanced emphysema patients.

The findings are being presented May 20, 2003, at the American Thoracic Society 99th International Conference in Seattle, Wash., and posted simultaneously on the New England Journal of Medicine Web site (www.nejm.org). They will also appear in the May 22 print edition of the journal.

Johns Hopkins was the coordinating center for NETT researchers at the clinical sites that studied survival, exercise ability, lung function, quality of life, shortness of breath, and illness and hospitalization rates of 1,218 patients followed for an average of 29 months. At the start of the study, each patient underwent six to 10 weeks of pulmonary rehabilitation, which included education, counseling and exercise training, believed to help patients understand and manage their condition and make the most of their ability to perform activities of daily living. The participants were then randomly divided into one group of 608 patients who received surgery and ongoing medical management, and another group of 610 patients who got management but not surgery.

Emphysema is a progressive, chronic and disabling lung condition that affects an estimated 2 million Americans, primarily individuals over age 50 who are current or former cigarette smokers. With emphysema, breathing becomes difficult as the fine architecture of the lung is destroyed, leading to large holes in the lung, obstructed airways and trapping of air because of reduced elasticity of the lungs. According to the NIH, emphysema costs more than $2.5 billion in annual health care expenses and causes or contributes to 100,000 deaths in the United States each year.

###Other Johns Hopkins researchers involved in the study are H. Fessler, J. Tonascia, P. Belt, K. Collins, B. Collison, J. Dodge, M. Donithan, V. Edmonds, J. Fuller, J. Harle, R. Jackson, H. Koppelman, S. Lee, C. Levine, H. Livingston, J. Meinert, J. Meyers, D. Nowakowski, K. Owens, S. Qi, M. Smith, B. Simon, P. Smith, A. Sternberg, M. Van Natta, and L. Wilson. The study was funded by the National Heart, Lung and Blood Institute (NHLBI), the Centers for Medicare and Medicaid Services, and the Agency for Healthcare Research and Quality.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Benefits of Lung Surgery Reported for Emphysema Patients." ScienceDaily. ScienceDaily, 21 May 2003. <www.sciencedaily.com/releases/2003/05/030521092235.htm>.
Johns Hopkins Medical Institutions. (2003, May 21). Benefits of Lung Surgery Reported for Emphysema Patients. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2003/05/030521092235.htm
Johns Hopkins Medical Institutions. "Benefits of Lung Surgery Reported for Emphysema Patients." ScienceDaily. www.sciencedaily.com/releases/2003/05/030521092235.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins