Featured Research

from universities, journals, and other organizations

Tissue Engineered Bone Grows Strong

Date:
June 26, 2003
Source:
Whitaker Foundation
Summary:
By closely following nature's blueprint, Toronto researchers have developed an innovative way to speed the healing of severe bone breaks, resulting in what may be the thickest tissue-engineered bone ever produced in the laboratory.

ARLINGTON, Va., June 25, 2003 -- By closely following nature's blueprint, Toronto researchers have developed an innovative way to speed the healing of severe bone breaks, resulting in what may be the thickest tissue-engineered bone ever produced in the laboratory.

The new bone grows naturally without the addition of chemical growth stimulants, said Whitaker investigator Molly Shoichet, Ph.D., of the University of Toronto. The innovation is in the design of the synthetic scaffold that provides a framework for the growing tissue.

The design mimics the structure of natural bone so faithfully that some experts in the field cannot distinguish between the two when shown micrographs of each side-by-side, Shoichet said. The research was published in the June 15 issue of the Journal of Biomedical Materials Research Part A.

"The structure is very open and porous," she said. "There are large interconnections between the pores separated by struts, rather than solid walls."

Into this spongy matrix, the researchers drizzle bone marrow cells, which can differentiate into osteoblasts, the strong, mineral-like cells of mature bone. The marrow cells take up residence in the scaffold and begin growing and multiplying. As they mature, the scaffold itself dissolves.

"You don't need growth factors to get the cells into the scaffold," Shoichet said. "The cells almost fall through it and get stuck along the way."

The scaffold, developed with coinvestigator John Davies of the University of Toronto, is made of poly(lactide-co-glycolide), a polymer used in sutures. The polymer is processed in a unique way to yield the open, sponge-like structure with pores more than 10 times larger than those that result from conventional processing.

Animal studies show that the scaffold provides an intricate framework for dense new bone growth while it slowly dissolves. In rabbits, strong new bone completely replaced the scaffold in about eight weeks.

For some time, tissue engineers have experimented with scaffolds that promote bone growth. Much of this work has relied on supplementing the cell culture with growth hormones or other stimulating chemicals. Shoichet demonstrates a simpler, more natural way to grow new bone.

"To the best of our knowledge, bone growth throughout such a volume has not been reported before in the literature," she said.

The University of Toronto has licensed the technology to BoneTec Corp. for commercial development under the trademark name of Osteofoam. Shoichet is a vice president of the company.

The Whitaker Foundation has supported Shoichet's laboratory through a 1998 Biomedical Engineering Research Grant for research to encourage the regrowth of damaged nerve cells.


Story Source:

The above story is based on materials provided by Whitaker Foundation. Note: Materials may be edited for content and length.


Cite This Page:

Whitaker Foundation. "Tissue Engineered Bone Grows Strong." ScienceDaily. ScienceDaily, 26 June 2003. <www.sciencedaily.com/releases/2003/06/030626074418.htm>.
Whitaker Foundation. (2003, June 26). Tissue Engineered Bone Grows Strong. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2003/06/030626074418.htm
Whitaker Foundation. "Tissue Engineered Bone Grows Strong." ScienceDaily. www.sciencedaily.com/releases/2003/06/030626074418.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins