Featured Research

from universities, journals, and other organizations

Sleep Deprivation Within Five Hours Of Learning Impairs Memory Consolidation In Mice

Date:
July 9, 2003
Source:
University Of Pennsylvania
Summary:
Scientists at the University of Pennsylvania have found new support for the age-old advice to "sleep on it." Mice allowed to sleep after being trained remembered what they had learned far better than those deprived of sleep for several hours afterward.

PHILADELPHIA -- Scientists at the University of Pennsylvania have found new support for the age-old advice to "sleep on it." Mice allowed to sleep after being trained remembered what they had learned far better than those deprived of sleep for several hours afterward.

Related Articles


The researchers also determined that the five hours following learning are crucial for memory consolidation; mice deprived of sleep five to 10 hours after learning a task showed no memory impairment. The results are reported in the May/June issue of the journal Learning & Memory.

"Memory consolidation happens over a period of hours after training for a task, and certain cellular processes have to occur at precise times," said senior author Ted Abel, assistant professor of biology at Penn. "We set out to pinpoint the specific window of time and area of the brain that are sensitive to sleep deprivation after learning."

Abel and his colleagues found that sleep deprivation zero to five hours after learning appeared to impair spatial orientation and recognition of physical surroundings, known as contextual memory. Recollection of specific facts or events, known as cued memory, was not affected. Because the brain's hippocampus is key to contextual memory but not cued memory, the findings provide new evidence that sleep helps regulate neuronal function in the hippocampus.

Abel's group studied fear conditioning in mice. Animals received a mild electric shock in conjunction with one of two different types of stimuli. Some mice were placed in a distinctive setting before receiving a shock, generating fear of that particular location. Others heard a tone shortly before a shock was administered, causing them to fear the tone.

Abel assessed the permanence of this fear conditioning by observing how frequently the mice froze -- remaining completely motionless for a number of seconds -- when exposed 24 hours later to the cue associated with the shock. Even when deprived of sleep, mice exposed to the audible tone remained fearful the following day.

But mice that had learned to associate a general physical environment with administration of an electric shock were less likely to do so after sleep deprivation. Sleep-deprived mice spent just 4 percent of their time frozen when returned to this environment the following day, compared to 15 percent among mice whose sleep was not disrupted in the five hours immediately after shock administration.

"It has been suggested that sleep serves a variety of physiological functions, ranging from energy conservation to refreshing the immune system," Abel said. "Another important hypothesis is that sleep regulates neuronal function during memory consolidation. Our findings provide support for this theory, and, by implicating hippocampal-dependent tasks during a specific time window, we have taken an initial step in clarifying the neural effects of sleep deprivation."

Abel's co-authors are Laurel A. Graves and Allan I. Pack of Penn's School of Medicine and Penn undergraduate Elizabeth A. Heller.


Story Source:

The above story is based on materials provided by University Of Pennsylvania. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania. "Sleep Deprivation Within Five Hours Of Learning Impairs Memory Consolidation In Mice." ScienceDaily. ScienceDaily, 9 July 2003. <www.sciencedaily.com/releases/2003/07/030709064042.htm>.
University Of Pennsylvania. (2003, July 9). Sleep Deprivation Within Five Hours Of Learning Impairs Memory Consolidation In Mice. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2003/07/030709064042.htm
University Of Pennsylvania. "Sleep Deprivation Within Five Hours Of Learning Impairs Memory Consolidation In Mice." ScienceDaily. www.sciencedaily.com/releases/2003/07/030709064042.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins