Featured Research

from universities, journals, and other organizations

Non-steroidal Anti-inflammatory Drug Applied To Skin Lessens Muscle Soreness After Exercise

Date:
July 14, 2003
Source:
University Of California - San Diego
Summary:
Researchers at the University of California, San Diego (UCSD) School of Medicine have shown that a non-steroidal anti-inflammatory drug (NSAID) applied as a cream directly to the skin is safe and effective in lessening muscle soreness experienced 24 to 48 hours following exercise, when soreness reaches its peak.

Researchers at the University of California, San Diego (UCSD) School of Medicine have shown that a non-steroidal anti-inflammatory drug (NSAID) applied as a cream directly to the skin is safe and effective in lessening muscle soreness experienced 24 to 48 hours following exercise, when soreness reaches its peak. In addition, the direct application bypasses the internal body-route taken by oral medications, thus avoiding unpleasant side effects sometimes experienced with NSAIDs.

Related Articles


In a study published in the July issue of the Clinical Journal of Sport Medicine, the investigators compared a transdermal (cream) version of an NSAID called ketoprofen against a cream version of a placebo, in a study with 32 healthy males between the ages of 18 and 35 years. Women were not included to avoid fertility or pregnancy complications.

At 48 hours following exercise, the study volunteers who used the NSAID cream reported 37 to 45 percent less muscle soreness than those who used a placebo.

Currently, oral NSAIDs are the most commonly prescribed medications for pain relief and reduction of inflammation experienced after exercise. However, individuals experience significant systemic side effects, such as gastrointestinal distress and problems with liver and kidney function. Annually, an estimated 103,000 patients are hospitalized each year in the U.S. for NSAID-induced gastrointestinal complications, and more than 16,000 NSAID-related deaths occur each year among arthritis patients alone.

The research team did not expect side effects with the transdermal application of the NSAID, since only about one percent of medication directly applied to the skin is absorbed systemically. To verify this, the research team obtained blood samples from the participants, so to measure system absorption of ketoprofen, which is an indicator of potential side effects, such as gastrointestinal irritation. Using a liquid chromatography/mass spectrometry method, the investigators found that serum ketoprofen levels at 24 and 48 hours was minimal, even below the normal detection limit of 10 ng/mL.

The paper's authors noted that "if an effective transdermal method of NSAID delivery were available, these limitations of oral delivery could be avoided. Further, a transdermal delivery system would have the advantage of delivering NSAIDs directly to the desired location."

However, transdermal formulations of NSAIDs are not commercially available in the U.S. Physicians must prescribe a customized, individual compound that is prepared by pharmacists.

The researchers noted that additional studies would be needed to evaluate the efficacy of long-term treatment with transdermal ketoprofen, and the efficacy of the drug in treating chronic inflammatory conditions such as arthritis.

The study was funded by Trans-Pharma Pharmaceutical Co., which makes the transdermal cream version of ketoprofen.

The paper's senior author was Mark D. Bracker, M.D., a UCSD professor of family and preventive medicine; the first author was Christopher R. Cannavino, M.D., a resident in the UCSD Department of Pediatrics. Additional contributors were Lawrence A. Palinkas, Ph.D., UCSD professor of family and preventive medicine, Anthony Salimbeni, M.D., a former faculty member in the UCSD Department of Family and Preventive Medicine, and Jeffrey Abrams, M.D., MPH, director of product development, Trans-Pharma Pharmaceutical Co.


Story Source:

The above story is based on materials provided by University Of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - San Diego. "Non-steroidal Anti-inflammatory Drug Applied To Skin Lessens Muscle Soreness After Exercise." ScienceDaily. ScienceDaily, 14 July 2003. <www.sciencedaily.com/releases/2003/07/030714091533.htm>.
University Of California - San Diego. (2003, July 14). Non-steroidal Anti-inflammatory Drug Applied To Skin Lessens Muscle Soreness After Exercise. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2003/07/030714091533.htm
University Of California - San Diego. "Non-steroidal Anti-inflammatory Drug Applied To Skin Lessens Muscle Soreness After Exercise." ScienceDaily. www.sciencedaily.com/releases/2003/07/030714091533.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins