Featured Research

from universities, journals, and other organizations

Microbubbles Can Image Blood Vessel Growth In Tumors

Date:
July 16, 2003
Source:
University Of Virginia Health System
Summary:
Imagine being able to quickly detect and diagnose blood vessel growth in cancerous tumors, and even predict how fast the tumors might metastasize or spread. Researchers at the University of Virginia Health System are doing just that in animal models using millions of tiny microbubbles injected into the bloodstream, coupled with contrast-enhanced ultrasound, an inexpensive and widely-used technique using sound waves to "see" inside the body.

CHARLOTTESVILLE, Va., July 15 – Imagine being able to quickly detect and diagnose blood vessel growth in cancerous tumors, and even predict how fast the tumors might metastasize or spread. Researchers at the University of Virginia Health System are doing just that in animal models using millions of tiny microbubbles injected into the bloodstream, coupled with contrast-enhanced ultrasound, an inexpensive and widely-used technique using sound waves to "see" inside the body. Their findings are published in the July 22 edition of the journal Circulation, available online at http://circ.ahajournals.org/.

"For the first time, this research shows that scientists can detect cancer using ultrasound contrast agents targeted to abnormal blood vessels that reside within tumors," said Dr. Jonathan Lindner, a U.Va. cardiologist and primary author of the study. "By assessing how much new blood vessel growth there is, we can detect tumors and metastatic spread at a very early stage."

Lindner said the one of the first signs of tumor and metastasis is a remodeling of surrounding blood vessels in the normal tissue near a tumor. The tumor activates the process of growth of new blood vessels called angiogenesis, supplying nutrients and oxygen to the tumor and keeping it alive.

To detect angiogenesis in and around a tumor, Dr. Lindner's research group developed microbubbles targeted to the endothelial (inner) lining of new blood vessels. Microbubbles are normally about half the size of a red blood cell and are composed of a gas surrounded by a shell. They are currently being used worldwide to image blood flow and heart function in patients.

In their experiments, Lindner's team at U.Va. attached molecules of echistatin, derived from viper venom, to the surface of each microbubble and injected the bubbles intravenously into mice with brain tumors. The echistatin molecule caused the bubbles to bind to a molecular component (an integrin) called alpha-v beta-3, which is expressed in the lining, or endothelium, of new blood vessels. After just ten minutes, the targeted microbubbles, and new blood vessels, appeared in bright colors on an ultrasound image.

"We may soon be able to assess cancer prognosis on patients using a technique like this. The more angiogenesis, the more aggressive a tumor is likely to be," Lindner said. "This microbubble technique may be able to tell people and their physicians exactly what's likely to happen with a tumor in the future. If we know it has a certain amount of angiogenesis, then we know a tumor might be susceptible to treatment with new anti-tumor or anti-neoplastic agents developed to shrink tumors."

The U.Va. researchers were also able to use microbubbles to image capillary blood flow in tumors. They found that blood flow has a high velocity on the periphery of the tumors, but a much slower velocity inside a tumor. Blood flow velocity is a potentially important marker for tumor detection, Lindner said.

Linder and his U.Va. team first used microbubbles to detect angiogenesis in animal models, but not tumors. Their earlier findings were published in the January 28, 2003 edition of Circulation.


Story Source:

The above story is based on materials provided by University Of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University Of Virginia Health System. "Microbubbles Can Image Blood Vessel Growth In Tumors." ScienceDaily. ScienceDaily, 16 July 2003. <www.sciencedaily.com/releases/2003/07/030716090025.htm>.
University Of Virginia Health System. (2003, July 16). Microbubbles Can Image Blood Vessel Growth In Tumors. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2003/07/030716090025.htm
University Of Virginia Health System. "Microbubbles Can Image Blood Vessel Growth In Tumors." ScienceDaily. www.sciencedaily.com/releases/2003/07/030716090025.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins