Featured Research

from universities, journals, and other organizations

HIV Infection May Bump Up Risk Of Heart Disease In Younger Patients, UCLA Study Finds

Date:
July 25, 2003
Source:
University Of California - Los Angeles
Summary:
HIV-positive adults ages 18 to 34 may be more likely to suffer coronary heart disease than HIV-negative persons their age, a new UCLA study suggests. Reported in the August issue of the Journal of Acquired Immune Deficiency Syndromes, the findings emphasize the need for physicians to monitor HIV patients' cardiac health.

HIV-positive adults ages 18 to 34 may be more likely to suffer coronary heart disease than HIV-negative persons their age, a new UCLA study suggests. Reported in the August issue of the Journal of Acquired Immune Deficiency Syndromes, the findings emphasize the need for physicians to monitor HIV patients' cardiac health.

"Our study suggests that coronary heart disease may be accelerated in younger HIV-infected people," said Dr. Judith Currier, a researcher at the UCLA AIDS Institute and associate professor of infectious diseases at the David Geffen School of Medicine at UCLA. "It's important for physicians to incorporate heart-disease risk prevention into HIV primary care."

Currier and her associates reviewed six years of claims data from 28,513 HIV-positive Medi-Cal patients and 3,054,696 HIV-negative Medi-Cal patients. Both groups were 18 or older and had been free of heart disease for at least one year from Medi-Cal enrollment. The scientists did not include patients whose coronary heart-disease diagnosis preceded their HIV infection diagnosis.

After adjusting for available data on age, gender, antiretroviral therapy, hypertension and diabetes, Currier and her colleagues compared the rate and risk for coronary heart disease between the two populations. Then the researchers evaluated the relationship between the HIV patients' use of antiretroviral therapy and the number of first-time coronary heart-disease incidents in their group.

Currier's team uncovered a number of surprising results:

* The rate of coronary heart disease in HIV-infected men aged 18 to 34 and HIV-infected women aged 18 to 44 -- while very low -- was still statistically significantly higher than in HIV-negative people in those age groups. For example, the rate of coronary heart disease in 18- to 34-year-old HIV-positive men was 1.64 incidents per 100 patient years compared to 0.76 incidents per 100 patient years in HIV-negative men.

* In HIV-infected men under 34 and HIV-infected women under 45 on antiretroviral therapy, the rate of coronary heart disease was twice the rate of their HIV-positive counterparts who never took the drugs.

* There were no statistically significant links between antiretroviral therapy and HIV, or between HIV and coronary heart disease, in men over 34 and women over 44.

"Coronary heart disease is rare in younger people," said Currier, associate director of the UCLA Center for Clinical AIDS Research and Education. "Yet HIV infection appears to slightly elevate young adults' risk for heart disease when compared to HIV-negative persons their age."

The findings also suggest a slight association between antiretroviral therapy and increased coronary heart-disease risk in younger but not older HIV-infected patients, she said.

"The results of this study should not diminish clinicians' enthusiasm for antiretroviral therapy to treat their patients' HIV infection," Currier emphasized. "The benefits of antiretroviral therapy in slowing HIV progression and prolonging patients' lives outweigh its possible cardiac risks."

Currier pointed out that more studies are needed to investigate whether specific antiretroviral therapy agents contribute to coronary heart-disease risk.

"Our study was not able to examine the role of specific antiretroviral drugs and increased cardiac risk," she said. "Clearly, more research is needed in this area to draw firm conclusions."

Currier theorizes that HIV infection may have less influence on older patients' health, because other health conditions and lifestyle choices overshadow the virus' effect.

"As people with HIV live longer, their physicians need to address the other diseases that affect HIV-negative patients at their age," Currier said.

The Bristol-Myers Squibb Co. funded the study. Currier's co-authors included Dr. Anne Taylor, University of Minnesota School of Medicine; Felicity Boyd, Johns Hopkins University Bloomberg School of Public Health; and Christopher Dezii, Hugh Kawabata, Beth Burtcel, Jen-Fue Maa and Sally Hodder, Bristol-Myers Squibb Co.


Story Source:

The above story is based on materials provided by University Of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Los Angeles. "HIV Infection May Bump Up Risk Of Heart Disease In Younger Patients, UCLA Study Finds." ScienceDaily. ScienceDaily, 25 July 2003. <www.sciencedaily.com/releases/2003/07/030725075829.htm>.
University Of California - Los Angeles. (2003, July 25). HIV Infection May Bump Up Risk Of Heart Disease In Younger Patients, UCLA Study Finds. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2003/07/030725075829.htm
University Of California - Los Angeles. "HIV Infection May Bump Up Risk Of Heart Disease In Younger Patients, UCLA Study Finds." ScienceDaily. www.sciencedaily.com/releases/2003/07/030725075829.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins