Featured Research

from universities, journals, and other organizations

SARS Information For Antiviral Drug Design Released By Protein Data Bank

Date:
July 31, 2003
Source:
Rutgers, The State University Of New Jersey
Summary:
The Protein Data Bank (PDB), an international resource for biomedical research with facilities at Rutgers, The State University of New Jersey, has released to the public a three-dimensional crystal structure of the SARS virus main protease enzyme.

NEW BRUNSWICK/PISCATAWAY, N.J. -- The Protein Data Bank (PDB), an international resource for biomedical research with facilities at Rutgers, The State University of New Jersey, has released to the public a three-dimensional crystal structure of the SARS virus main protease enzyme. Its availability to medical researchers worldwide is crucial because this enzyme is considered the primary target for new antiviral drugs being developed to combat the virus.

Related Articles


"The PDB was able to process and release this information so quickly because of the leading-edge technology it employs," said Rutgers Board of Governors Professor of Chemistry and Chemical Biology Helen M. Berman, director of the Protein Data Bank. "It is critically important that these kinds of data are made available quickly to expedite the drug discovery process, especially when we are dealing with a potentially epidemic disease like SARS. The rapid processing possible by the PDB is going to become increasingly important as we release structures with such medically important potential."

The actual structure determination was made by Structural GenomiX, Inc., a biotechnology company in San Diego. The company deposited its data with the PDB, which were processed rapidly by a team at Rutgers to make the data available in the public database.

"Having the three-dimensional structure of the SARS virus protease should accelerate the search for effective treatments for SARS," said Eddy Arnold, professor, Rutgers' department of chemistry and chemical biology. "Structure-based drug design has had an important impact on the development of anti-AIDS drugs that are now in use, and the rapid progress with characterizing the SARS coronavirus will enable more efficient paths to developing drugs for treating SARS. The PDB renders an important service to the research community in providing rapid access to this crucial information."

The Protein Data Bank is an Internet-accessible international resource for three-dimensional information on biological macromolecules. As a tool to help unlock the secrets of biological systems in medical and pharmaceutical research, the PDB is a critical asset to 21st century genomic research and drug design. Research Collaboratory for Structural Bioinformatics (RCSB) members Rutgers, the San Diego Supercomputer Center at UCSD, and the Center for Advanced Research in Biotechnology of the National Institute of Standards and Technology manage the PDB.


Story Source:

The above story is based on materials provided by Rutgers, The State University Of New Jersey. Note: Materials may be edited for content and length.


Cite This Page:

Rutgers, The State University Of New Jersey. "SARS Information For Antiviral Drug Design Released By Protein Data Bank." ScienceDaily. ScienceDaily, 31 July 2003. <www.sciencedaily.com/releases/2003/07/030731081515.htm>.
Rutgers, The State University Of New Jersey. (2003, July 31). SARS Information For Antiviral Drug Design Released By Protein Data Bank. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2003/07/030731081515.htm
Rutgers, The State University Of New Jersey. "SARS Information For Antiviral Drug Design Released By Protein Data Bank." ScienceDaily. www.sciencedaily.com/releases/2003/07/030731081515.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins