Featured Research

from universities, journals, and other organizations

Study Shows New Drug Reduces Advanced Parkinson's Disease Symptoms

Date:
August 18, 2003
Source:
University Of South Florida Health Sciences Center
Summary:
After 40 years of treating Parkinson's disease with dopamine medications, a new study shows potential for a non-dopamine drug that may provide benefit for patients with advanced Parkinson's disease.

Tampa, FL (August 13, 2003) -- After 40 years of treating Parkinson's disease with dopamine medications, a new study shows potential for a non-dopamine drug that may provide benefit for patients with advanced Parkinson's disease.

Related Articles


Robert A. Hauser, M.D., first author of the study and director of the Parkinson's Disease and Movement Disorders Center at the University of South Florida, and other researchers across the United States, found istradefylline (KW-6002) reduced by 1.7 hours per day the time that advanced Parkinson's disease patients experienced tremors, slowness and stiffness. Istradefylline did not worsen the severity of dyskinesias and was generally well tolerated by participants.

The study, sponsored by Kyowa Pharmaceuticals, Inc., appears in the August 13, 2003, issue of the journal Neurology.

Patients with Parkinson's disease have less control over motor function and experience worsening tremors, slowness and stiffness as the disease advances. Current dopamine replacement therapy improves those symptoms, but after several years the treatment becomes complicated by a shortened duration of benefit and the emergence of twisting, turning movements called dyskinesias. Once this occurs, increasing dopamine medication worsens dyskinesias and reducing dopamine medication allows a worsening of slowness, stiffness, and tremors.

"Once patients with Parkinson's disease develop both motor fluctuations and dyskinesias, it is very difficult to provide further benefit with dopamine medications," said Dr. Hauser. "This study opens the door to the possibility of providing additional benefit for advanced Parkinson's disease patients and confirms the idea that medications that affect neurotransmitters other than dopamine can provide benefit in Parkinson's disease."

In this 12-week, double-blind, placebo-controlled study, 83 patients with motor fluctuations and dyskinesias on levodopa (a dopamine medication) were randomized to three groups. All participants continued their levodopa treatment. One group additionally received placebo, another up to 20 mg per day of istradefylline, and the last up to 40 mg per day of istradefylline.

Participants noted their status--whether they were asleep, OFF (medication benefit having worn off), ON (medication providing benefit) without dyskinesia or ON with dyskinesia--during half-hour intervals three times a week on home diaries.

Earlier studies in animal models of PD showed istradefylline exerts an antiparkinsonian effect without worsening dyskinesia. Istradefylline, an adenosine A2A receptor antagonist, changes the firing of neurons in a way that improves motor function in Parkinson's disease.

"More work is needed," Dr. Hauser said. "We may be able to reduce the time patients are OFF with slowness, stiffness, and tremors without worsening the severity of dyskinesias. With dopamine medications alone, this is difficult to do."

Other investigators for this study were Jean P. Hubble, MD, of the Ohio State University Department of Neurology, Columbus, OH; Daniel D. Truong, MD, of the Parkinson's and Movement Disorder Institute, Fountain Valley, CA; and the Istradefylline US-001 Study Group.

Drs. Hauser and Hubble received compensation from Kyowa for consultation related to the design and implementation of future studies.


Story Source:

The above story is based on materials provided by University Of South Florida Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of South Florida Health Sciences Center. "Study Shows New Drug Reduces Advanced Parkinson's Disease Symptoms." ScienceDaily. ScienceDaily, 18 August 2003. <www.sciencedaily.com/releases/2003/08/030814072525.htm>.
University Of South Florida Health Sciences Center. (2003, August 18). Study Shows New Drug Reduces Advanced Parkinson's Disease Symptoms. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2003/08/030814072525.htm
University Of South Florida Health Sciences Center. "Study Shows New Drug Reduces Advanced Parkinson's Disease Symptoms." ScienceDaily. www.sciencedaily.com/releases/2003/08/030814072525.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins