Featured Research

from universities, journals, and other organizations

Trojan Horse Technique May Slow Growth Of Tumours

Date:
October 1, 2003
Source:
University Of Toronto
Summary:
Toronto scientists are taking a page from Greek legend by employing a Trojan Horse technique that may treat breast cancer proven resistant to chemotherapy.

Toronto scientists are taking a page from Greek legend by employing a Trojan Horse technique that may treat breast cancer proven resistant to chemotherapy.

A study in the September Journal of Nuclear Medicine found that a drug that combines a radioactive isotope called Indium-111 with an amino acid called epidermal growth factor (EGF) slowed the growth of large tumours three-fold and caused tiny tumours to regress when injected into mice.

"Like the legend of the Trojan Horse in which invading soldiers hid inside a hollow wooden horse to fool the enemy, this drug enables deadly radioisotopes to hide within the EGF as it passes naturally into the breast cancer cells," says senior author Professor Raymond Reilly of the University of Toronto's Leslie Dan Faculty of Pharmacy and Toronto General Hospital, University Health Network. "These radioisotopes cannot harm the cancer cell from the outside. The key is getting them into the cancer cell where their radioactive particles can destroy the cell's DNA."

The normal role of EGF is to bind to receptors on the surface of certain cells, including some breast cancer cells, to stimulate their growth. EGF later moves inside the cell to shut off the growth signal. Working on the theory that EGF can also transport other substances, the scientists created a drug - 111In-hEGF - that mixes EGF with the radioactive isotope Indium-111. Once injected into the body, the EGF portion carries the Indium-111 to the heart of the cancer cell. Breast cancer cells are especially susceptible to this drug because they use more EGF than normal cells, says Reilly, the study's senior author. Toronto General research technologist Paul Chen is the first author of the study, which received funding from the U.S. Army Breast Cancer Research Program and the Susan G. Komen Breast Cancer Foundation.

A team led by radiation and medical biophysics professor Dr. Katherine Vallis, a radiation oncologist at Princess Margaret Hospital, is launching the first phase of a clinical trial to test the safety of 111In-hEGF in patients with advanced, chemotherapy-resistant breast cancer. For more information on the trial, call 416-946-2121.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Trojan Horse Technique May Slow Growth Of Tumours." ScienceDaily. ScienceDaily, 1 October 2003. <www.sciencedaily.com/releases/2003/10/031001064310.htm>.
University Of Toronto. (2003, October 1). Trojan Horse Technique May Slow Growth Of Tumours. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2003/10/031001064310.htm
University Of Toronto. "Trojan Horse Technique May Slow Growth Of Tumours." ScienceDaily. www.sciencedaily.com/releases/2003/10/031001064310.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins