Featured Research

from universities, journals, and other organizations

Trojan Horse Technique May Slow Growth Of Tumours

Date:
October 1, 2003
Source:
University Of Toronto
Summary:
Toronto scientists are taking a page from Greek legend by employing a Trojan Horse technique that may treat breast cancer proven resistant to chemotherapy.

Toronto scientists are taking a page from Greek legend by employing a Trojan Horse technique that may treat breast cancer proven resistant to chemotherapy.

A study in the September Journal of Nuclear Medicine found that a drug that combines a radioactive isotope called Indium-111 with an amino acid called epidermal growth factor (EGF) slowed the growth of large tumours three-fold and caused tiny tumours to regress when injected into mice.

"Like the legend of the Trojan Horse in which invading soldiers hid inside a hollow wooden horse to fool the enemy, this drug enables deadly radioisotopes to hide within the EGF as it passes naturally into the breast cancer cells," says senior author Professor Raymond Reilly of the University of Toronto's Leslie Dan Faculty of Pharmacy and Toronto General Hospital, University Health Network. "These radioisotopes cannot harm the cancer cell from the outside. The key is getting them into the cancer cell where their radioactive particles can destroy the cell's DNA."

The normal role of EGF is to bind to receptors on the surface of certain cells, including some breast cancer cells, to stimulate their growth. EGF later moves inside the cell to shut off the growth signal. Working on the theory that EGF can also transport other substances, the scientists created a drug - 111In-hEGF - that mixes EGF with the radioactive isotope Indium-111. Once injected into the body, the EGF portion carries the Indium-111 to the heart of the cancer cell. Breast cancer cells are especially susceptible to this drug because they use more EGF than normal cells, says Reilly, the study's senior author. Toronto General research technologist Paul Chen is the first author of the study, which received funding from the U.S. Army Breast Cancer Research Program and the Susan G. Komen Breast Cancer Foundation.

A team led by radiation and medical biophysics professor Dr. Katherine Vallis, a radiation oncologist at Princess Margaret Hospital, is launching the first phase of a clinical trial to test the safety of 111In-hEGF in patients with advanced, chemotherapy-resistant breast cancer. For more information on the trial, call 416-946-2121.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Trojan Horse Technique May Slow Growth Of Tumours." ScienceDaily. ScienceDaily, 1 October 2003. <www.sciencedaily.com/releases/2003/10/031001064310.htm>.
University Of Toronto. (2003, October 1). Trojan Horse Technique May Slow Growth Of Tumours. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2003/10/031001064310.htm
University Of Toronto. "Trojan Horse Technique May Slow Growth Of Tumours." ScienceDaily. www.sciencedaily.com/releases/2003/10/031001064310.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Ebola Cases Could Reach 1.4 Million Within 4 Months

Ebola Cases Could Reach 1.4 Million Within 4 Months

Newsy (Sep. 23, 2014) Health officials warn that without further intervention, the number of Ebola cases in Liberia and Sierra Leone could reach 1.4 million by January. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins