Featured Research

from universities, journals, and other organizations

Medication 'Wearing Off' A Bigger Problem For Parkinson's Patients Than Physicians May Realize

Date:
October 24, 2003
Source:
University Of South Florida Health Sciences Center
Summary:
Patients with Parkinson's disease (PD) who are taking levodopa therapy – the most widely-used agent to treat the illness – may experience the effects of their medication "wearing off" sooner than their health care providers realize.

TAMPA, FL (Oct. 23, 2003) – Patients with Parkinson's disease (PD) who are taking levodopa therapy – the most widely-used agent to treat the illness – may experience the effects of their medication "wearing off" sooner than their health care providers realize. New data presented Oct. 19 at the Parkinson's Study Group (PSG) meeting in San Francisco concluded that a specifically-designed patient questionnaire identified symptoms related to "wearing off" more frequently than a clinical assessment conducted by a movement disorder specialist.

Related Articles


"Although levodopa remains the foundation of Parkinson's disease therapy, the medical community has long recognized that its use can be limited due to the inability to control Parkinson's disease symptoms over time," said investigator Robert A. Hauser, M.D., M.B.A., director of the Parkinson's Disease and Movement Disorders Center of the University of South Florida in Tampa and member of an international consortium of researchers known as the End-of-Dose Wearing Off (EODWO) Working Group. "However, this study shows that end-of-dose 'wearing off' may be a bigger problem for Parkinson's disease patients than physicians and other members of the health care community realize."

Within one to two years, almost 50 percent of PD patients receiving levodopa therapy begin to notice that their medication lasts for shorter periods, causing symptoms to re-emerge before the next dose. This phenomenon is known as "wearing off." Eventually, the effect of a levodopa dose may decrease from eight hours when patients begin levodopa therapy to only one to two hours. "Wearing off" is associated with the re-emergence of motor symptoms (e.g. tremor and problems with balance), non-motor symptoms (e.g. anxiety, fatigue, mood changes, and restlessness), and autonomic nervous system dysfunction (e.g. sweating and hypersalivation).

"To date, the frequency of end-of-dose 'wearing off' in a general neurology practice is unknown, and no specific tools exist to aid clinical diagnoses of its signs and symptoms," said Dr. Hauser. "Because there are new medications available that can help to improve symptom control throughout more of the day, it is important for physicians to have a simple way to identify these symptoms."

A group of 10 international Movement Disorder specialists (the End-of-Dose Wearing Off Working Group) collaborated to assess prospectively whether or not a specifically designed patient questionnaire can identify the same or more subjects suffering from end-of-dose "wearing off" than a clinical assessment. The blinded study used the AliProject, a web-enabled database of patients treated at participating Parkinson's disease research centers in the United States. The clinical database was developed by the Muhammed Ali Parkinson Research Center.

Three hundred patients diagnosed with Parkinson's disease participated in the study. All were age 30 or older, and had Parkinson's disease for less than 5 years. Of the 289 patients who completed the study, 87.5% were on levodopa therapy versus other anti-parkinsonian medications. The duration of levodopa therapy for these patients was 1.96+1.53 years.

Investigators found that the clinical assessment identified "wearing off" in 85 patients (29.4%) compared with 165 patients (57.1%) who self-reported symptoms of "wearing off" on the patient questionnaire. When asked about difficulties associated with these symptoms, 40% of respondents indicated that the symptoms were at least very troublesome. The most commonly listed troublesome symptoms included tremor, balance difficulty, and reduced dexterity.

Parkinson's disease, a chronic and progressive neurological condition, affects approximately 1.5 million Americans. Symptoms include limbs that tremble; slowness of movement; stiffness and rigidity of limbs and gait or balance problems. As the disease progresses, these symptoms usually increase and impact a person's ability to work and function.


Story Source:

The above story is based on materials provided by University Of South Florida Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of South Florida Health Sciences Center. "Medication 'Wearing Off' A Bigger Problem For Parkinson's Patients Than Physicians May Realize." ScienceDaily. ScienceDaily, 24 October 2003. <www.sciencedaily.com/releases/2003/10/031024063402.htm>.
University Of South Florida Health Sciences Center. (2003, October 24). Medication 'Wearing Off' A Bigger Problem For Parkinson's Patients Than Physicians May Realize. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2003/10/031024063402.htm
University Of South Florida Health Sciences Center. "Medication 'Wearing Off' A Bigger Problem For Parkinson's Patients Than Physicians May Realize." ScienceDaily. www.sciencedaily.com/releases/2003/10/031024063402.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins