Featured Research

from universities, journals, and other organizations

NIAMS Researchers Collaborate To Produce Targeted Immunosuppressant Drug

Date:
November 3, 2003
Source:
NIH/National Institute Of Arthritis And Musculoskeletal And Skin Diseases
Summary:
The new drug, discovered by Pfizer researchers, may be of major importance for those who are treated with immunosuppressants for organ transplants or autoimmune diseases.

Investigators at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Pfizer Global Research and Development and Stanford University have collaborated in studying a new immunosuppressant drug, CP-690,550, that may avoid some of the common side effects associated with other medications that curb the immune system. The new drug, discovered by Pfizer researchers, may be of major importance for those who are treated with immunosuppressants for organ transplants or autoimmune diseases.

John O'Shea, M.D., Yong-Jie Zhou, M.D., and their team in the NIAMS Molecular Immunology and Inflammation Branch joined scientists from Pfizer and Stanford in developing and studying the drug. CP-690,550 was tested in mice with heart transplants and in monkeys with kidney transplants done by Stanford. In both cases, animals treated with CP-690,550 survived much longer than untreated animals. None of the treated animals showed signs of such immunosuppressant side effects as increased cholesterol, blood sugar, blood pressure or increased white blood cell count. The animals also showed no significant decreases in white blood cells or platelets.

The new drug, reported in the journal Science, inhibits the enzyme Jak3, a protein discovered by the NIAMS team in 1994 that is found only in immune system cells. The new study shows that inhibiting this enzyme has the effect of suppressing the immune system, while not affecting other systems of the body. Current immunosuppressant drugs target enzymes found in cells throughout the body, resulting in the toxic side effects. The Jak3 inhibitor has the advantage of selectively targeting a protein that only has effects on immune cells.

The finding culminates a long process of research and discovery by the NIAMS team. After discovering Jak3, the team demonstrated that this protein, called a kinase, was critical for the cell signaling process resulting in the development of infection-fighting white blood cells. They went on to show that the mutation of the gene encoding Jak3 was responsible for a form of severe combined immunodeficiency (SCID). Because Jak3 is essential for immune cell function, and because its expression is limited to blood cells, the team proposed that inhibiting Jak3 might be the basis for a new class of immunosuppressant drugs. The group then entered into a collaborative research and development agreement with Pfizer -- a partnership that has enabled Pfizer to develop this new drug.

CP-690,550 is the first Jak3 inhibitor to show positive results in primates. Further animal studies are being conducted to determine if this drug could be used successfully and safely in humans.

Immunosuppressant drugs, which inhibit the body's immune response, are given to prevent the body from rejecting transplanted organs, and are also used to treat autoimmune diseases such as lupus, rheumatoid arthritis, eczema and psoriasis. Autoimmune diseases cause the immune system to attack healthy, normal tissue as if it were a foreign substance. The finding that CP-690,550 selectively suppresses the immune response in transplant rejection with minimal toxicity also suggests that a Jak3 inhibitor might be useful in the treatment of autoimmune diseases.

###

The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the Department of Health and Human Services' National Institutes of Health, is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases. For more information about NIAMS, call the information clearinghouse at 301-495-4484 or 877-22-NIAMS (free call) or visit the NIAMS Web site at http://www.niams.nih.gov. Changelian P, et al. Prevention of organ allograft rejection by a specific Janus Kinase 3 inhibitor. Science, 2003;302:875-878.


Story Source:

The above story is based on materials provided by NIH/National Institute Of Arthritis And Musculoskeletal And Skin Diseases. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute Of Arthritis And Musculoskeletal And Skin Diseases. "NIAMS Researchers Collaborate To Produce Targeted Immunosuppressant Drug." ScienceDaily. ScienceDaily, 3 November 2003. <www.sciencedaily.com/releases/2003/10/031031063138.htm>.
NIH/National Institute Of Arthritis And Musculoskeletal And Skin Diseases. (2003, November 3). NIAMS Researchers Collaborate To Produce Targeted Immunosuppressant Drug. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2003/10/031031063138.htm
NIH/National Institute Of Arthritis And Musculoskeletal And Skin Diseases. "NIAMS Researchers Collaborate To Produce Targeted Immunosuppressant Drug." ScienceDaily. www.sciencedaily.com/releases/2003/10/031031063138.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins