Featured Research

from universities, journals, and other organizations

Stem Cells From Human Peripheral Blood Protect Against Acute Stroke In Rats

Date:
November 14, 2003
Source:
University Of South Florida Health Sciences Center
Summary:
Enriched stem cells from the circulating blood of human donors improved functional recovery when transplanted into the brains of rats with strokes, report researchers from the University of South Florida College of Medicine and Medical College of Georgia.

Tampa, FL -- Enriched stem cells from the circulating blood of human donors improved functional recovery when transplanted into the brains of rats with strokes, report researchers from the University of South Florida College of Medicine and Medical College of Georgia.

Paul Sanberg, PhD, DSc, professor of neurosurgery and director of the USF Center for Excellence in Aging and Brain Repair, will present the findings today at the Society for Neuroscience Meeting in New Orleans.

The researchers demonstrated that cells obtained from circulating human blood -- known as human peripheral blood (HPB) cells -- survived without immunosuppression, migrated to the site of stroke injury and significantly improved motor and cognitive performance in transplanted animals.

In addition, the researchers tracked the migration of the HPB cells following transplant by marking the cells with a fluorescent green protein that lights up under a microscope. They found that cell migration increased when HPB cell grafts were transplanted into the area of brain threatened but not yet dead (ischemic penumbra). No HPB cell migration was observed when cells were transplanted into the area of the brain where nearly all tissue had already died. (ischemic core).

Brain damage in both the striatum and cortex, sites of stroke injury, was 30 to 35 percent less in HPB-transplanted rats than in the control animals.

The researchers conclude the preliminary findings support the investigation of HPB cells for neurotransplantation therapy in stroke patients. They also suggest that the penumbra may be a more suitable transplant target than the core when designing clinical trials.


Story Source:

The above story is based on materials provided by University Of South Florida Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of South Florida Health Sciences Center. "Stem Cells From Human Peripheral Blood Protect Against Acute Stroke In Rats." ScienceDaily. ScienceDaily, 14 November 2003. <www.sciencedaily.com/releases/2003/11/031113065024.htm>.
University Of South Florida Health Sciences Center. (2003, November 14). Stem Cells From Human Peripheral Blood Protect Against Acute Stroke In Rats. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2003/11/031113065024.htm
University Of South Florida Health Sciences Center. "Stem Cells From Human Peripheral Blood Protect Against Acute Stroke In Rats." ScienceDaily. www.sciencedaily.com/releases/2003/11/031113065024.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins