Featured Research

from universities, journals, and other organizations

Stem Cells From Human Peripheral Blood Protect Against Acute Stroke In Rats

Date:
November 14, 2003
Source:
University Of South Florida Health Sciences Center
Summary:
Enriched stem cells from the circulating blood of human donors improved functional recovery when transplanted into the brains of rats with strokes, report researchers from the University of South Florida College of Medicine and Medical College of Georgia.

Tampa, FL -- Enriched stem cells from the circulating blood of human donors improved functional recovery when transplanted into the brains of rats with strokes, report researchers from the University of South Florida College of Medicine and Medical College of Georgia.

Related Articles


Paul Sanberg, PhD, DSc, professor of neurosurgery and director of the USF Center for Excellence in Aging and Brain Repair, will present the findings today at the Society for Neuroscience Meeting in New Orleans.

The researchers demonstrated that cells obtained from circulating human blood -- known as human peripheral blood (HPB) cells -- survived without immunosuppression, migrated to the site of stroke injury and significantly improved motor and cognitive performance in transplanted animals.

In addition, the researchers tracked the migration of the HPB cells following transplant by marking the cells with a fluorescent green protein that lights up under a microscope. They found that cell migration increased when HPB cell grafts were transplanted into the area of brain threatened but not yet dead (ischemic penumbra). No HPB cell migration was observed when cells were transplanted into the area of the brain where nearly all tissue had already died. (ischemic core).

Brain damage in both the striatum and cortex, sites of stroke injury, was 30 to 35 percent less in HPB-transplanted rats than in the control animals.

The researchers conclude the preliminary findings support the investigation of HPB cells for neurotransplantation therapy in stroke patients. They also suggest that the penumbra may be a more suitable transplant target than the core when designing clinical trials.


Story Source:

The above story is based on materials provided by University Of South Florida Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of South Florida Health Sciences Center. "Stem Cells From Human Peripheral Blood Protect Against Acute Stroke In Rats." ScienceDaily. ScienceDaily, 14 November 2003. <www.sciencedaily.com/releases/2003/11/031113065024.htm>.
University Of South Florida Health Sciences Center. (2003, November 14). Stem Cells From Human Peripheral Blood Protect Against Acute Stroke In Rats. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2003/11/031113065024.htm
University Of South Florida Health Sciences Center. "Stem Cells From Human Peripheral Blood Protect Against Acute Stroke In Rats." ScienceDaily. www.sciencedaily.com/releases/2003/11/031113065024.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins