Featured Research

from universities, journals, and other organizations

Jefferson Scientists Find Radiation And Blood Vessel Inhibitor More Effective Against Brain Tumors

Date:
November 25, 2003
Source:
Thomas Jefferson University
Summary:
Combining radiation with an agent that blocks VEGF, a protein that promotes the development of blood vessels and the growth of cancerous tumors – a process known as angiogenesis – may be more effective against brain tumors than either treatment alone, researchers at Jefferson Medical College have found.

Combining radiation with an agent that blocks VEGF, a protein that promotes the development of blood vessels and the growth of cancerous tumors – a process known as angiogenesis – may be more effective against brain tumors than either treatment alone, researchers at Jefferson Medical College have found.

Scientists led by Phyllis Wachsberger, Ph.D., assistant professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and Adam Dicker, M.D., associate professor of radiation oncology at Jefferson Medical College, looked at whether adding radiation changed the effectiveness of a drug called VEGF Trap on the growth of a common brain tumor, glioblastoma, in a mouse model. VEGF Trap is a protein engineered to block VEGF activity. The particular type of brain tumor expresses high levels of VEGF and is resistant to treatment with many other antiangiogenic drugs.

According to Dr. Dicker, who is also director of the Division of Experimental Radiation Oncology at Jefferson's Kimmel Cancer Center, the findings indicate that radiation may in many cases substantially enhance the drug's anti-tumor activity. In fact, research results from Jefferson and other laboratories indicate that VEGF Trap may be as much as 1,000 times more potent in controlling cancerous tumor growth than angiogenesis inhibitors now under review by the Food and Drug Administration, he says.

Dr. Wachsberger presents the group's work November 19 at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.

"These are the first studies showing a potential benefit of this agent and radiation," Dr. Dicker says.

The scientists compared the effects of both small and large doses of VEGF Trap on tumor growth in mice that either had or didn't have radiation treatments. In the study, radiation alone delayed tumor growth for 10 days more than control mice, to which no treatment had been given. Radiation plus low-dose VEGF Trap increased the growth delay by 20 to 25 days more than the control. High-dose VEGF Trap did even better, adding an extra 40 days of growth delay, though in this case the researchers didn't see any benefit from adding radiation.

Next, says Dr. Dicker, the Jefferson group hopes to refine the use of radiation with VEGF Trap, including getting a better idea of specific doses and their timing and effectiveness.

###

Regeneron Pharmaceuticals, Inc., in Tarrytown, NY, funded the research.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Jefferson Scientists Find Radiation And Blood Vessel Inhibitor More Effective Against Brain Tumors." ScienceDaily. ScienceDaily, 25 November 2003. <www.sciencedaily.com/releases/2003/11/031120073956.htm>.
Thomas Jefferson University. (2003, November 25). Jefferson Scientists Find Radiation And Blood Vessel Inhibitor More Effective Against Brain Tumors. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2003/11/031120073956.htm
Thomas Jefferson University. "Jefferson Scientists Find Radiation And Blood Vessel Inhibitor More Effective Against Brain Tumors." ScienceDaily. www.sciencedaily.com/releases/2003/11/031120073956.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins