Featured Research

from universities, journals, and other organizations

Oral Drug Showing Promise For Breast Cancer Prevention In A Mouse Model

Date:
December 26, 2003
Source:
Journal Of The National Cancer Institute
Summary:
The oral drug ZD1839, also known as gefitinib, prevented the development of estrogen receptor (ER)-negative breast cancer in a mouse model, which raises the possibility that the drug could be a preventive agent for ER-negative breast cancer. The results appear in the December 17 issue of the Journal of the National Cancer Institute.

The oral drug ZD1839, also known as gefitinib, prevented the development of estrogen receptor (ER)-negative breast cancer in a mouse model, which raises the possibility that the drug could be a preventive agent for ER-negative breast cancer. The results appear in the December 17 issue of the Journal of the National Cancer Institute.

ER-negative breast cancers are not dependent on estrogen to grow and do not respond to antiestrogen drugs such as tamoxifen and raloxifene. ZD1839, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, blocks the cellular signaling pathway that contributes to tumor survival and growth, and studies have shown that ZD1839 is effective at inhibiting the growth of various types of cancer cells, including breast cancer cells.

To test whether ZD1839 can inhibit the growth of ER-negative breast cancer cells, Chunhua Lu, M.D., Ph.D., and Powel H. Brown, M.D., Ph.D., of the Baylor College of Medicine in Houston, and their colleagues treated ER-negative normal, immortalized (i.e., precancerous), and cancerous breast cells with ZD1839. They also examined the effect of ZD1839 on the development of ER-negative breast tumors in transgenic mice.

Treatment with ZD1839 suppressed the growth of ER-negative normal, immortalized, and cancerous breast cells. Moreover, ZD1839 treatment of transgenic mice that normally develop breast tumors in approximately 230 days delayed the formation of ER-negative tumors to more than 310 days. ZD1839 also reduced proliferation of normal breast cells by 20.3% and of tumor cells by 42%.

In an accompanying editorial, Dennis J. Slamon, M.D., Ph.D., of the University of California at Los Angeles Jonsson Comprehensive Cancer Center, and his colleagues commend the new findings, but caution that long-term safety data are not available for ZD1839. They point out that some patients taking ZD1839 for non–small-cell lung cancer have developed interstitial lung disease, a rare but potentially dangerous side effect, particularly if ZD1839 is used as a chemopreventive agent in healthy women.

In addition, they say, the effectiveness of ZD1839 and other EGFR inhibitors may be limited to a subpopulation of patients in whom EGFR is involved in tumor formation or growth. "Before we develop gefitinib as a chemopreventive agent, further research is needed to find and validate predictive factors that can be used to identify patients and healthy women likely to respond to gefitinib as a therapeutic and chemopreventive agent," they conclude.

###

Editorial: Kim Irwin, Jonsson Comprehensive Cancer Center, 310-206-2805, kirwin@mednet.ucla.edu. Lu C, Speers C, Zhang Y, Xu X, Hill J, Steinbis E, et al. Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor–negative mammary tumors. J Natl Cancer Inst 2003;95:1825–33.

Editorial: Konecny GE, Wilcon CA, Slamon DJ. Is there a role for epidermal growth factor receptor inhibitors in breast cancer prevention. J Natl Cancer Inst 2003;95:1813–15.

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oupjournals.org/.


Story Source:

The above story is based on materials provided by Journal Of The National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The National Cancer Institute. "Oral Drug Showing Promise For Breast Cancer Prevention In A Mouse Model." ScienceDaily. ScienceDaily, 26 December 2003. <www.sciencedaily.com/releases/2003/12/031223065655.htm>.
Journal Of The National Cancer Institute. (2003, December 26). Oral Drug Showing Promise For Breast Cancer Prevention In A Mouse Model. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2003/12/031223065655.htm
Journal Of The National Cancer Institute. "Oral Drug Showing Promise For Breast Cancer Prevention In A Mouse Model." ScienceDaily. www.sciencedaily.com/releases/2003/12/031223065655.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins