Featured Research

from universities, journals, and other organizations

JAMA Study Shows New 'biologic' Drug Reduces Psoriasis Symptoms, Improves Quality Of Life

Date:
December 24, 2003
Source:
Loyola University Health System
Summary:
A new "biologic" drug, efalizumab, reduces the thick, red, scaly skin lesions of psoriasis, and improves patient quality of life, according to a study in the Dec. 17 Journal of the American Medical Association.

MAYWOOD, Ill. – A new "biologic" drug, efalizumab, reduces the thick, red, scaly skin lesions of psoriasis, and improves patient quality of life, according to a study in the Dec. 17 Journal of the American Medical Association.

"Biologics are a new approach to treating psoriasis," said lead author Dr. Kenneth Gordon, director of the Loyola Psoriasis Center, Loyola University Health System, Maywood, Ill. "The symptom relief with biologics is achieved without many of the side effects of traditional psoriasis treatment."

Gordon and colleagues conducted a double-blind, placebo-controlled study of efalizumab on 556 adult psoriasis patients at 30 centers in the U.S. and Canada. Patients received weekly injections of the drug or a placebo for three months. Researchers assessed the extent of the psoriasis on the head, upper and lower limbs, and trunk of each patient. In addition, they rated the degree of scaling and thickness.

"Psoriasis is triggered by an immune system response that induces skin cells to grow too quickly," said Gordon, associate professor of medicine, division of dermatology, Loyola University Chicago Stritch School of Medicine, Maywood, Ill. "The skin cells also do not mature normally. As a result, the skin piles up and forms red, scaly, thick plaque lesions.

For the study, patients completed a questionnaire asking how psoriasis affects their daily life, work and their relationships. They also reported symptoms, including pain, itching, bleeding, burning and scaling.

"Biologics are injected, instead of swallowed, and block immune cells that produce the dry, flaky skin," said Gordon, who serves on the National Psoriasis Foundation's medical board. Efalizumab modulates T-cells. Found in the blood supply, T-cells bolster the body's immune response.

The researchers evaluated the effects of efalizumab on health-related quality of life measures from both patient and physician perspective. "Psoriasis can compromise physical, social and emotional well-being," said Gordon.

Results of the study shows that the patients who received the biologic therapy achieve significant improvement vs. placebo.

"The efalizumab treatment reduced the frequency and severity of psoriasis symptoms, particularly in the severity of itching and scaling," said Gordon.

Psoriasis can develop at any age, although it usually shows up in 15- to 35-year-olds. Average age at diagnosis: 28 years. Earlier medicines for psoriasis had side effects, such as liver or kidney toxicity. Psoriasis can be triggered by stress, certain medicines or injury to the skin. Because 33 percent of people with psoriasis have a family history of the disease, it is impossible to know who will get psoriasis.

Affecting five million Americans (average age at diagnosis: 28 years), psoriasis has no cure but effective new treatments are emerging with medications called "biologics."

"No medicine is appropriate for everyone," said Gordon. "Individuals must check with their doctor before pursuing any psoriasis therapy."

Visit the Loyola University Health System Web site http://www.luhs.org for more information. To schedule an appointment with Gordon, call (708) 216-3835.

Gordon has received research finding from Genentech, Inc.


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Cite This Page:

Loyola University Health System. "JAMA Study Shows New 'biologic' Drug Reduces Psoriasis Symptoms, Improves Quality Of Life." ScienceDaily. ScienceDaily, 24 December 2003. <www.sciencedaily.com/releases/2003/12/031223070303.htm>.
Loyola University Health System. (2003, December 24). JAMA Study Shows New 'biologic' Drug Reduces Psoriasis Symptoms, Improves Quality Of Life. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2003/12/031223070303.htm
Loyola University Health System. "JAMA Study Shows New 'biologic' Drug Reduces Psoriasis Symptoms, Improves Quality Of Life." ScienceDaily. www.sciencedaily.com/releases/2003/12/031223070303.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins