Featured Research

from universities, journals, and other organizations

Researchers A Step Further In Type 1 Diabetes Treatment; Single Infusion Of Islet Cells Surpasses Previous Success

Date:
February 24, 2004
Source:
University Of Minnesota
Summary:
Researchers at the University of Minnesota's Diabetes Institute for Immunology and Transplantation (DIIT) and the University of California San Francisco (UCSF) Diabetes Center have achieved insulin independence in four of six patients with long-term Type 1 diabetes using one infusion of insulin-producing "islet" cells from a single donor pancreas.

Researchers at the University of Minnesota's Diabetes Institute for Immunology and Transplantation (DIIT) and the University of California San Francisco (UCSF) Diabetes Center have achieved insulin independence in four of six patients with long-term Type 1 diabetes using one infusion of insulin-producing "islet" cells from a single donor pancreas.

Related Articles


Individuals in whom Type 1 diabetes was complicated by hypoglycemic unawareness participated in this trial. The combination of improved islet preparation techniques and optimized recipient immunosuppression contributed to the successful study outcome. Insulin independence has now been maintained for more than one year in four recipients, for more than two years in three recipients, and for more than three years in two recipients. The study, funded primarily by the Juvenile Diabetes Research Foundation, is published in the March issue of the American Journal of Transplantation.

"This success builds upon other recent successes in islet transplantation and marks a critical step in developing islet transplants into a vital treatment option for people with Type 1 diabetes", said Dr. Bernhard Hering, associate professor of surgery, holder of the Eunice L. Dwan Diabetes Research Chair at the University of Minnesota, and principal investigator of the study.

"This trial also brings us a step closer to minimizing the requirements for immunosuppression in islet transplant recipients," said Dr. Jeffrey Bluestone, professor of medicine and director of the Diabetes Center at UCSF, and co-principal investigator of the study.

Dr. Bluestone developed the new generation anti-CD3 monoclonal antibody that was administered in this trial during the first two weeks after transplant. This antibody is directed against the subset of white blood cells that cause Type 1 diabetes and mediate rejection of transplants. Study participants received two other immunosuppression drugs.

In a subsequent trial supported by the NIH Immune Tolerance Network (www.immunetolerance.org), the research team at the University of Minnesota and UCSF will test whether maintenance immunosuppressive medication can be minimized or even discontinued in islet transplant recipients given the anti-CD3 antibody.

"The demonstration in this pilot clinical trial that insulin independence can be induced in Type 1 diabetes with single donor islet transplants is quite important because it will allow an increased number of islet transplants to be performed, and at the same time, will decrease the risk and cost of the procedure", Richard Insel, M.D., executive vice president of research at the Juvenile Diabetes Research Foundation.

###

For the complete study, please visit http://www.blackwellpublishing.com, or visit the DIIT's website at http://www.diabetesinstitute.org.

The Diabetes Institute for Immunology and Transplantation (DIIT) was formed in 1994 to capitalize on the University of Minnesota's historic leadership in pancreas and islet cell transplantation. Both of these advanced treatments for diabetes were pioneered here. Under the leadership of David E.R. Sutherland, M.D., Ph.D., both procedures have continued to be refined. The University of Minnesota is the home of the world's oldest, largest pancreas transplant program, having performed over 1,500 pancreas transplants, which are frequently preceded, accompanied or succeeded by a kidney transplant.


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Researchers A Step Further In Type 1 Diabetes Treatment; Single Infusion Of Islet Cells Surpasses Previous Success." ScienceDaily. ScienceDaily, 24 February 2004. <www.sciencedaily.com/releases/2004/02/040224104659.htm>.
University Of Minnesota. (2004, February 24). Researchers A Step Further In Type 1 Diabetes Treatment; Single Infusion Of Islet Cells Surpasses Previous Success. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2004/02/040224104659.htm
University Of Minnesota. "Researchers A Step Further In Type 1 Diabetes Treatment; Single Infusion Of Islet Cells Surpasses Previous Success." ScienceDaily. www.sciencedaily.com/releases/2004/02/040224104659.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins