Featured Research

from universities, journals, and other organizations

Researchers A Step Further In Type 1 Diabetes Treatment; Single Infusion Of Islet Cells Surpasses Previous Success

Date:
February 24, 2004
Source:
University Of Minnesota
Summary:
Researchers at the University of Minnesota's Diabetes Institute for Immunology and Transplantation (DIIT) and the University of California San Francisco (UCSF) Diabetes Center have achieved insulin independence in four of six patients with long-term Type 1 diabetes using one infusion of insulin-producing "islet" cells from a single donor pancreas.

Researchers at the University of Minnesota's Diabetes Institute for Immunology and Transplantation (DIIT) and the University of California San Francisco (UCSF) Diabetes Center have achieved insulin independence in four of six patients with long-term Type 1 diabetes using one infusion of insulin-producing "islet" cells from a single donor pancreas.

Individuals in whom Type 1 diabetes was complicated by hypoglycemic unawareness participated in this trial. The combination of improved islet preparation techniques and optimized recipient immunosuppression contributed to the successful study outcome. Insulin independence has now been maintained for more than one year in four recipients, for more than two years in three recipients, and for more than three years in two recipients. The study, funded primarily by the Juvenile Diabetes Research Foundation, is published in the March issue of the American Journal of Transplantation.

"This success builds upon other recent successes in islet transplantation and marks a critical step in developing islet transplants into a vital treatment option for people with Type 1 diabetes", said Dr. Bernhard Hering, associate professor of surgery, holder of the Eunice L. Dwan Diabetes Research Chair at the University of Minnesota, and principal investigator of the study.

"This trial also brings us a step closer to minimizing the requirements for immunosuppression in islet transplant recipients," said Dr. Jeffrey Bluestone, professor of medicine and director of the Diabetes Center at UCSF, and co-principal investigator of the study.

Dr. Bluestone developed the new generation anti-CD3 monoclonal antibody that was administered in this trial during the first two weeks after transplant. This antibody is directed against the subset of white blood cells that cause Type 1 diabetes and mediate rejection of transplants. Study participants received two other immunosuppression drugs.

In a subsequent trial supported by the NIH Immune Tolerance Network (www.immunetolerance.org), the research team at the University of Minnesota and UCSF will test whether maintenance immunosuppressive medication can be minimized or even discontinued in islet transplant recipients given the anti-CD3 antibody.

"The demonstration in this pilot clinical trial that insulin independence can be induced in Type 1 diabetes with single donor islet transplants is quite important because it will allow an increased number of islet transplants to be performed, and at the same time, will decrease the risk and cost of the procedure", Richard Insel, M.D., executive vice president of research at the Juvenile Diabetes Research Foundation.

###

For the complete study, please visit http://www.blackwellpublishing.com, or visit the DIIT's website at http://www.diabetesinstitute.org.

The Diabetes Institute for Immunology and Transplantation (DIIT) was formed in 1994 to capitalize on the University of Minnesota's historic leadership in pancreas and islet cell transplantation. Both of these advanced treatments for diabetes were pioneered here. Under the leadership of David E.R. Sutherland, M.D., Ph.D., both procedures have continued to be refined. The University of Minnesota is the home of the world's oldest, largest pancreas transplant program, having performed over 1,500 pancreas transplants, which are frequently preceded, accompanied or succeeded by a kidney transplant.


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Researchers A Step Further In Type 1 Diabetes Treatment; Single Infusion Of Islet Cells Surpasses Previous Success." ScienceDaily. ScienceDaily, 24 February 2004. <www.sciencedaily.com/releases/2004/02/040224104659.htm>.
University Of Minnesota. (2004, February 24). Researchers A Step Further In Type 1 Diabetes Treatment; Single Infusion Of Islet Cells Surpasses Previous Success. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2004/02/040224104659.htm
University Of Minnesota. "Researchers A Step Further In Type 1 Diabetes Treatment; Single Infusion Of Islet Cells Surpasses Previous Success." ScienceDaily. www.sciencedaily.com/releases/2004/02/040224104659.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins