Featured Research

from universities, journals, and other organizations

Transdermal Patch As Effective As Intravenous Pump For Post-op Pain Control

Date:
March 17, 2004
Source:
Journal Of The American Medical Association
Summary:
Use of a transdermal patch to deliver pain medication was found to be equivalent to medication delivered by an intravenous pump for controlling pain following surgery, according to a study in the March 17 issue of The Journal of the American Medical Association (JAMA).

Use of a transdermal patch to deliver pain medication was found to be equivalent to medication delivered by an intravenous pump for controlling pain following surgery, according to a study in the March 17 issue of The Journal of the American Medical Association (JAMA).

Related Articles


Patient-controlled analgesia (PCA) allows the patient to self-administer small doses of opioids, such as fentanyl and morphine, as needed to control pain, according to background information in the article. PCA with an intravenous (IV) pump with morphine is a common method of providing postoperative pain control after major surgery. The fentanyl hydrochloride patient-controlled transdermal system (PCTS) eliminates the need for the use of needles, intravenous tubing, a large pump, and does not hinder mobility. The transdermal system is a self-adhesive unit, about the size of a credit card, and is worn on the patient's upper arm or chest. It delivers small doses of fentanyl into the skin, where it then diffuses into the local circulation and is transported to the central nervous system.

Eugene R. Viscusi, M.D., of Thomas Jefferson University, Philadelphia, and colleagues conducted a study to determine whether the transdermal PCA delivery system is equivalent to a standard morphine IV PCA regimen in postoperative pain management. The trial included 636 adult patients who had just undergone major surgery between September 2000 and March 2001 at 33 North American hospitals. In surgical recovery rooms, patients were randomly assigned to intravenous morphine by a patient-controlled analgesia pump (n = 320) or fentanyl hydrochloride by a patient-controlled transdermal system (n = 316).

The researchers found that fentanyl hydrochloride PCTS and IV PCA morphine were equivalent according to the primary end point of ratings of pain control during the first 24-hour treatment period. Ratings of good or excellent pain control were reported by 73.7 percent of patients who received fentanyl PCTS and 76.9 percent of patients who received IV PCA morphine.

"Early patient discontinuations (25.9 percent fentanyl vs. 25.0 percent morphine) and last pain intensity scores (32.7 fentanyl vs. 31.1 morphine on the visual analog scale) were not different between the 2 treatments. With continued treatment for up to 48 or 72 hours, more than 80 percent of patient assessments in each treatment group were good or excellent. The incidence of opioid-related adverse events was similar between the groups," the researchers write.

###

(JAMA. 2004;291:1333-1341. Available post-embargo at JAMA.com)

Editor's Note: ALZA Corporation, Mountain View, Calif., supported the study in its entirety. Co-authors Drs. Atkinson and Khanna own stock in Johnson & Johnson, the parent company of Alza Corporation.


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "Transdermal Patch As Effective As Intravenous Pump For Post-op Pain Control." ScienceDaily. ScienceDaily, 17 March 2004. <www.sciencedaily.com/releases/2004/03/040317074116.htm>.
Journal Of The American Medical Association. (2004, March 17). Transdermal Patch As Effective As Intravenous Pump For Post-op Pain Control. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2004/03/040317074116.htm
Journal Of The American Medical Association. "Transdermal Patch As Effective As Intravenous Pump For Post-op Pain Control." ScienceDaily. www.sciencedaily.com/releases/2004/03/040317074116.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins