Featured Research

from universities, journals, and other organizations

Vanderbilt Study Shows Cold Drug Ingredient Could Cause Strokes

Date:
April 20, 2004
Source:
Vanderbilt University Medical Center
Summary:
A common ingredient in over-the-counter decongestants -- pseudoephedrine -- may increase blood pressure and the risk of life-threatening or disabling strokes in susceptible patients.

A common ingredient in over-the-counter decongestants -- pseudoephedrine -- may increase blood pressure and the risk of life-threatening or disabling strokes in susceptible patients, researchers at Vanderbilt University Medical Center have reported.

Related Articles


"At the usual doses, (pseudoephedrine) is probably safe for most people," says Italo Biaggioni, M.D., professor of Medicine and Pharmacology and director of the Vanderbilt Clinical Trials Center. "The concern for the general population is there might be susceptible individuals who might respond to normal doses of these medications with dangerous increasing blood pressure and even strokes."

People at potential risk may include those with high blood pressure, a history of previous strokes, and diabetes – a disease that can damage the nerves that help maintain normal blood pressure.

Biaggioni recommends that people check their blood pressure an hour after taking a decongestant containing pseudoephedrine. If blood pressure rises, "you know you shouldn’t continue to take it," he says. "Having a cold makes your life miserable, but nobody dies of nasal stuffiness."

In a study placed on the Web site of the medical journal Circulation this week, Biaggioni and his colleagues found that blood pressure increased significantly in 13 patients with autonomic failure when they swallowed a small dose of pseudoephedrine and 16 ounces of water. Autonomic failure is the inability to control blood pressure. It is easier to study the impact of medications on blood pressure in patients who lack the normal neurological mechanisms for blood pressure regulation.

Systolic blood pressure (a measure of the maximum pressure exerted when the heart contracts) increased by an average of 52 millimeters of mercury in these patients one hour after they were given 30 milligrams of pseudoephedrine with the water. "Extended release" over-the-counter decongestants may contain 120 milligrams of pseudoephedrine, to be taken twice daily.

The patients in this study are disabled because their blood pressure drops precipitously when they stand, causing them to faint. This condition is known as orthostatic hypotension. Used cautiously, the combination of pseudoephedrine and water can prevent blood pressure from plunging when the patients stand, and therefore can be given as a treatment their condition. However, the researchers would not give the combination without first determining the patients’ susceptibility to pseudoephedrine.

The problem occurs when susceptible people unknowingly take these over-the-counter medications without medical supervision, Biaggioni says.

Four years ago, another decongestant, phenylpropanolamine, was pulled from the market because of an association with hemorrhagic (bleeding) strokes. The U.S. Food and Drug Administration recently announced plans to ban ephedra-containing dietary supplements because they also can raise blood pressure and increase the risk of stroke. "The chemical structure of ephedra and pseudoephedrine is exactly the same," Biaggioni notes.

It is not known to what extent pseudoephedrine-containing products increase the risk of stroke. But some studies have documented strokes in patients after they took recommended doses of the pseudoephedrine. "In the long-term, I think it will be better if we find a safer alternative" for decongestants, Biaggioni says.

The lead author of the Vanderbilt study was Jens Jordan, M.D., a former Vanderbilt post-doctoral fellow in clinical pharmacology who is now a professor at Humboldt University in Berlin, Germany. Others included John R. Shannon, M.D., Andrι Diedrich, M.D., Bonnie Black, R.N., and David Robertson, M.D., of the Vanderbilt Departments of Medicine and Pharmacology.

The research was supported by the National Institutes of Health and conducted with the assistance of General Clinical Research Center at Vanderbilt.


Story Source:

The above story is based on materials provided by Vanderbilt University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Vanderbilt University Medical Center. "Vanderbilt Study Shows Cold Drug Ingredient Could Cause Strokes." ScienceDaily. ScienceDaily, 20 April 2004. <www.sciencedaily.com/releases/2004/04/040416013002.htm>.
Vanderbilt University Medical Center. (2004, April 20). Vanderbilt Study Shows Cold Drug Ingredient Could Cause Strokes. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2004/04/040416013002.htm
Vanderbilt University Medical Center. "Vanderbilt Study Shows Cold Drug Ingredient Could Cause Strokes." ScienceDaily. www.sciencedaily.com/releases/2004/04/040416013002.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins