Featured Research

from universities, journals, and other organizations

New Hereditary Gene Linked To Parkinson's Disease

Date:
April 16, 2004
Source:
University College London
Summary:
University College London scientists have discovered a new gene implicated in the early development of Parkinson's disease.

UCL scientists have discovered a new gene implicated in the early development of Parkinson's disease. In a study of families with early onset disease, Professor Nick Wood and colleagues at UCL's Institute of Neurology identified a novel gene which produces a malfunctioning protein that could pave the way for new treatments for Parkinson sufferers.

The international study involving 14 research centres, published today in Science Express, mapped the genes in two Italian and one Spanish family where cousins had married and produced offspring.

Following earlier work tracing the chromosome location of the gene responsible for this form of familial Parkinson's disease, researchers were able to pinpoint mutations in the gene of the affected families. The mutations in PINK1 (PTEN-induced kinase 1) leads to a dysfunction of the protein, which in turn reduces the ability of brain cells to protect themselves from stress.

Although likely to be found in only a small percentage of Parkinson sufferers, the discovery of this gene has revealed a completely novel and hitherto unconsidered pathway which opens the way to identifying new forms of therapeutic treatment.

The finding also places mitochondrial function at the centre of research into Parkinson's disease and potentially other neurodegenerative diseases like Alzheimer's, in particular the role of oxidative stress in brain cell degeneration.

Professor Nick Wood says: "This discovery will help us to understand better the molecular events which lead to this incurable neurodegenerative disease. It is really the start of the more challenging investigation into what this protein does normally and how, when it is mutated, it leads to Parkinson's disease."

Parkinson's disease normally affects 1 to 2 percent of the ageing population.


Story Source:

The above story is based on materials provided by University College London. Note: Materials may be edited for content and length.


Cite This Page:

University College London. "New Hereditary Gene Linked To Parkinson's Disease." ScienceDaily. ScienceDaily, 16 April 2004. <www.sciencedaily.com/releases/2004/04/040416013539.htm>.
University College London. (2004, April 16). New Hereditary Gene Linked To Parkinson's Disease. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2004/04/040416013539.htm
University College London. "New Hereditary Gene Linked To Parkinson's Disease." ScienceDaily. www.sciencedaily.com/releases/2004/04/040416013539.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins