Featured Research

from universities, journals, and other organizations

Severe Sepsis Causes Almost 10% Of Cancer Deaths

Date:
July 5, 2004
Source:
BioMed Central
Summary:
Severe sepsis, is a costly complication in hospitalized cancer patients causing around one in ten cancer deaths each year in the USA, according to an article published today in Critical Care. The excessive response to infection in patients with severe sepsis injures critical organs such as the lungs and kidneys.

Severe sepsis, is a costly complication in hospitalized cancer patients causing around one in ten cancer deaths each year in the USA, according to an article published today in Critical Care. The excessive response to infection in patients with severe sepsis injures critical organs such as the lungs and kidneys.

Related Articles


Dr Mark Williams and his colleagues from Eli Lilly & Co. in Indianapolis, and Health Process Management, LLC, Pennsylvania used data from six US states to analyze all the hospitalizations in 1999 and estimate the incidence of severe sepsis in cancer patients across the US, and the mortality rate of patients suffering from both conditions.

Almost 5% of the cancer patients that were hospitalized in the six states were found to have severe sepsis. When extrapolated to the rest of the USA, this corresponds to around 126,000 cases every year.

The data also showed that hospitalized patients with cancer and severe sepsis were more than five times as likely to die than cancer patients not suffering from severe sepsis. 37.8% of patients with cancer and severe sepsis died in hospital in comparison to 7.2% of patients with cancer but no severe sepsis. This corresponds to the death of around 46,700 patients every year.

"Our study demonstrates the devastating complication of severe infections in cancer patients. Improvement in infection control, such as early appropriate antibiotics, in this population could have a significant impact on overall cancer survival," said Williams.

Cancer treatments and the presence of tumors can cause patients with cancer to become immunosuppressed. This hinders their ability to fight off infection, and makes them more at risk of severe sepsis than the general population.

In general, cancer patients were nearly four times as likely to be hospitalized with severe sepsis than people without cancer. Patients suffering from lymphoma, leukemia or other blood cancers were even more susceptible to severe sepsis than those suffering from cancer of a solid organ.

Patients with a blood cancer were 15 times more likely than the average person to suffer from severe sepsis. This higher rate corresponds to the fact that these patients are likely to be more severely immunocompromised than patients with other forms of cancer.

"We found that severe sepsis is a common, deadly, and costly complication in cancer patients," write the authors. "This complication was associated with nearly a three-fold increase in the time spent in hospital. We estimate that the annual hospital costs for these patients exceed US$3 billion annually"

###

This press release is based on the following article:

Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care Mark D Williams, LeeAnn Braun, Lisl M Cooper, Joseph Johnston, Richard V Weiss, Rebecca L Qualy and Walter Linde-Zwirble Critical Care 2004, 8:R291-R298

Upon publication this article will be available free of charge according to Critical Care's Open Access policy at http://ccforum.com/content/8/5/R291

###

Critical Care (http://ccforum.com/home) is published by BioMed Central (http://www.biomedcentral.com), an independent online publishing house committed to providing Open Access to peer-reviewed biological and medical research. This commitment is based on the view that immediate free access to research and the ability to freely archive and reuse published information is essential to the rapid and efficient communication of science. BioMed Central currently publishes over 100 journals across biology and medicine. In addition to open-access original research, BioMed Central also publishes reviews, commentaries and other non-original-research content. Depending on the policies of the individual journal, this content may be open access or provided only to subscribers.


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Severe Sepsis Causes Almost 10% Of Cancer Deaths." ScienceDaily. ScienceDaily, 5 July 2004. <www.sciencedaily.com/releases/2004/07/040705081428.htm>.
BioMed Central. (2004, July 5). Severe Sepsis Causes Almost 10% Of Cancer Deaths. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2004/07/040705081428.htm
BioMed Central. "Severe Sepsis Causes Almost 10% Of Cancer Deaths." ScienceDaily. www.sciencedaily.com/releases/2004/07/040705081428.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins