Featured Research

from universities, journals, and other organizations

Bone Marrow Cells Can Produce Epithelial Cells Without Fusion

Date:
July 5, 2004
Source:
Yale University
Summary:
Epithelial cells derived from bone marrow cells can be a result of differentiation, not fusion, according to a study published in Science by Yale researchers who arrived at some of the earliest findings on non-blood cells derived from bone marrow.

New Haven, Conn. -- Epithelial cells derived from bone marrow cells can be a result of differentiation, not fusion, according to a study published in Science by Yale researchers who arrived at some of the earliest findings on non-blood cells derived from bone marrow.

Led by Diane Krause, associate professor of Laboratory Medicine and Pathology at Yale School of Medicine, the investigators transplanted marrow-derived cells from male mice into female mice. They followed the fate of the marrow-derived cells (male) by detecting the Y chromosome. If resulting epithelial cells were formed by cell-to-cell fusion, they should express green fluorescent protein (GFP) and not beta-galactosidase.

"Our results show that under normal circumstances, the green fluorescent protein was not expressed, which means that no fusion has occurred and that the marrow derived cells can become non-blood cells without fusing," said Krause, attending physician in Laboratory Medicine at Yale-New Haven Hospital.

Krause said they did find that when the tissues were damaged, there were some cells that expressed GFP and therefore were derived from donor cells fusing with recipient cells.

Several years ago Krause's laboratory published a study showing that bone marrow stem cells can differentiate into liver, lung, kidney, skin, muscle and other cells. Later studies published by other researchers postulated that the bone marrow derived cells had actually fused with epithelial cells.

Krause said the ramifications of these latest findings are still unclear. "The absence of fusion in this model does not necessarily imply that trans-differentiation, a change in phenotype of one mature cell type to that of another mature cell type, has occurred," she said. "In fact, we carefully refrain from using that terminology in this report to avoid making assumptions about the mechanism of the phenotypic change."

She said it may be that an as-yet-unidentified, multipotent epithelial precursor exists in the bone marrow or that a separate population of marrow precursors exhibit a gene expression pattern that can be reprogrammed to express markers of other cell types.

Co-authors include Robert Harris, Erica Herzog, Emanuela Bruscia, Joanna Grove, and John Van Arnam.

###

Citation: Science, Vol. 305, pp 90-93 (July 2, 2004)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Bone Marrow Cells Can Produce Epithelial Cells Without Fusion." ScienceDaily. ScienceDaily, 5 July 2004. <www.sciencedaily.com/releases/2004/07/040705082112.htm>.
Yale University. (2004, July 5). Bone Marrow Cells Can Produce Epithelial Cells Without Fusion. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2004/07/040705082112.htm
Yale University. "Bone Marrow Cells Can Produce Epithelial Cells Without Fusion." ScienceDaily. www.sciencedaily.com/releases/2004/07/040705082112.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins