Featured Research

from universities, journals, and other organizations

Antibiotics Gain Strength With Natural Compound

Date:
July 22, 2004
Source:
University Of Rhode Island
Summary:
More and more common antibiotics are losing their effectiveness because they are used too often, allowing bacteria to develop resistance to the drugs. A University of Rhode Island researcher has found a solution to this problem with a natural compound that boosts antibiotic strength from 100 to 1,000 times.

KINGSTON, R.I. (July 20, 2004) -- More and more common antibiotics are losing their effectiveness because they are used too often, allowing bacteria to develop resistance to the drugs. A University of Rhode Island researcher has found a solution to this problem with a natural compound that boosts antibiotic strength from 100 to 1,000 times. While conducting research on infection prevention, URI Microbiology Professor Paul Cohen stumbled upon a compound -- lysophosphatidic acid -- that is naturally produced in the human body in great quantities wherever there is inflammation.

Related Articles


According to Cohen, bacteria are divided into two groups -- Gram-positive and Gram-negative -- based on the structure of their cell walls. When lysophosphatidic acid is administered in small amounts (80 micromolars), it sensitizes the Gram-negative bacteria 100 to 1,000 times so only small quantities of antibiotics are needed to kill the bacteria. When administered to fight Gram-positive bacteria, the compound kills the bacteria without needing any antibiotics.

"In combination with this compound, even older antibiotics become much more powerful," Cohen said. "It not only makes older antibiotics useful again, but it also allows them to be used in reduced dosages."

Lysophosphatidic acid is currently available commercially as a powder for researchers. Cohen holds a patent on its use with antibiotics. He said it can be formulated for a variety of applications, depending on where the infection is found.

"For cystic fibrosis patients, for instance, who often suffer from lung infections, it can be formulated for use as an inhalant. Burn patients or those with acne can use it as a lotion to rub on the skin. It can be applied in many ways," said the Narragansett resident who worked on the project with URI Professor David Laux, former URI technician Maryjane Utley and Danish researcher Karen Krogfelt of the Statenserum Institut in Copenhagen.

Cohen said that since the compound is naturally found in the bloodstream, it is non-toxic and patients should not be allergic to it. "We know it works in the test tube," he said, "but we still need to show that it works on animals. I'm sure that for surface diseases like acne, doctors would use it right away."

Cohen is seeking pharmaceutical-based partners to invest in the project and fund the next stage of research to bring this discovery to market.


Story Source:

The above story is based on materials provided by University Of Rhode Island. Note: Materials may be edited for content and length.


Cite This Page:

University Of Rhode Island. "Antibiotics Gain Strength With Natural Compound." ScienceDaily. ScienceDaily, 22 July 2004. <www.sciencedaily.com/releases/2004/07/040721090555.htm>.
University Of Rhode Island. (2004, July 22). Antibiotics Gain Strength With Natural Compound. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2004/07/040721090555.htm
University Of Rhode Island. "Antibiotics Gain Strength With Natural Compound." ScienceDaily. www.sciencedaily.com/releases/2004/07/040721090555.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins