Featured Research

from universities, journals, and other organizations

Early Results Show Promise For Strep Vaccine

Date:
August 11, 2004
Source:
Journal Of The American Medical Association
Summary:
Preliminary results from a trial for a streptococcal vaccine indicate the vaccine appears likely to offer protection against streptococcal infections, according to a study in the August 10 issue of JAMA, the Journal of the American Medical Association.

CHICAGO -- Preliminary results from a trial for a streptococcal vaccine indicate the vaccine appears likely to offer protection against streptococcal infections, according to a study in the August 10 issue of JAMA, the Journal of the American Medical Association.

Efforts to develop a vaccine to prevent group A streptococcal (a type of bacteria that commonly causes illness) infections have been ongoing for more than 70 years, according to background information in the article. Recent advances have allowed previous obstacles associated with group A streptococcal vaccine development to be overcome. Group A streptococcal infections and their sequelae represent a global health problem.

Karen L. Kotloff, M.D., of the University of Maryland School of Medicine, Baltimore, and colleagues report on a preliminary study evaluating the safety and immune reactivity of a group A streptococcal vaccine in healthy volunteers. The phase 1 vaccine trial included 28 adult volunteers aged 18 to 50 years recruited from the metropolitan area of Baltimore between October 1999 and February 2003. Each volunteer received 3 spaced intramuscular injections of either 50 micrograms (n=8), 100 micrograms (n=10), or 200 micrograms (n=10) of group A streptococcal vaccine formulated with aluminum hydroxide into the deltoid muscle of alternating arms.

"Our findings, albeit in a small number of participants, suggest that in the full dose range tested, the vaccine appears safe and well tolerated and does not evoke antibodies that cross-react with human tissue. We have identified a dose (200 micrograms) and schedule (0, 28, and 112 days) that appears to be capable of inducing immune responses... that are likely to confer protection against multiple group A streptococcal M types." (JAMA. 2004;292:709-715. Available post-embargo at jama.com)

Editor's Note: This study was supported by a U.S. Public Health Service contract from the National Institutes of Health to Myron M. Levine, M.D., and by grant and research funds from the Department of Veterans Affairs to co-author Dr. Dale. For the financial disclosures of the authors, please see the JAMA article.

EDITORIAL: CHALLENGES AHEAD FOR GROUP A STREPTOCOCCAL VACCINES

In an accompanying editorial, Michael E. Pichichero, M.D., of the University of Rochester Medical Center, Rochester, N.Y., writes that the challenges for successful development of group A streptococcal vaccines are substantial.

"Very stringent and early studies will lengthen the development process. Uncertainties about targeted immunologic parameters will complicate analysis. Most likely the proposed safety assessment will continue in adults and eventually will progress in phase 2 studies in children. Double-blind, placebo-controlled, stepwise evaluations in cohorts of children with declining age ranges should be anticipated. There will be a need to conduct large prelicensure trials involving 10,000 to 60,000 participants to provide assurance that rare adverse events are not associated with vaccination, particularly with M type vaccines that have demonstrated adverse events in the past. Safety concerns regarding cross-reaction with human tissues necessitates caution," Dr. Pichichero concludes. (JAMA. 2004;292:738-739. Available post-embargo at jama.com)


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "Early Results Show Promise For Strep Vaccine." ScienceDaily. ScienceDaily, 11 August 2004. <www.sciencedaily.com/releases/2004/08/040811082226.htm>.
Journal Of The American Medical Association. (2004, August 11). Early Results Show Promise For Strep Vaccine. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2004/08/040811082226.htm
Journal Of The American Medical Association. "Early Results Show Promise For Strep Vaccine." ScienceDaily. www.sciencedaily.com/releases/2004/08/040811082226.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins