Featured Research

from universities, journals, and other organizations

Scientists Discover Way To Slow The Progression Of Prostate Cancer

Date:
September 9, 2004
Source:
Imperial College London
Summary:
A UK based team of scientists and doctors have found a way to slow the development and spread of prostate cancer by stopping certain genes from becoming active.

A UK based team of scientists and doctors have found a way to slow the development and spread of prostate cancer by stopping certain genes from becoming active.

According to research published online in Oncogene, the team from Imperial College London, Cancer Research UK and Hammersmith Hospital have found a way to stop the development of cancer cells in the lab by limiting the effects of the androgen hormone and the genes which are activated by it. They have developed a way to silence these genes using an androgen receptor (AR) repressor, delivered by gene therapy.

Androgen is a hormone which is responsible for male characteristics and the development and function of male sexual organs. Scientists know that AR is active in virtually all prostate cancers, and the gene from the AR is frequently mutated.

Professor Jonathan Waxman, from Imperial College London and Hammersmith Hospital, and one of the researchers, comments: "Currently prostate cancer patients receive hormone therapy which stops the androgen receptor from producing testosterone, but this new therapy could prove much more effective in stopping the development of cancer.

"By using this repressor we can stop the genes from becoming active, and hopefully limit the development of cancer. We hope to combine using this repressor with existing cancer treatments to help develop newer, more effective methods to treat cancer."

The androgen receptor plays a key role in the development and progression of cancer. Currently doctors use anti-androgens to stop the genes regulated by the androgen receptor from being switched on, but the team have now discovered a repressor called PZLF, which has been fused with the AR to produce PLZF-AF, a combination of the two.

Professor Waxman adds: "Although this could be very good news for prostate cancer patients, we do need to be careful in interpreting the results. As yet we have not carried out these tests in patients, and getting the right delivery system will be key to this becoming an effective treatment, potentially helping many thousands of people in the UK alone."

The research was supported by Charing Cross and Hammersmith Hospitals Trustees, the Prostate Cancer Charity, Cancer Research UK and the Association for International Cancer Research.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Scientists Discover Way To Slow The Progression Of Prostate Cancer." ScienceDaily. ScienceDaily, 9 September 2004. <www.sciencedaily.com/releases/2004/09/040908081541.htm>.
Imperial College London. (2004, September 9). Scientists Discover Way To Slow The Progression Of Prostate Cancer. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2004/09/040908081541.htm
Imperial College London. "Scientists Discover Way To Slow The Progression Of Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2004/09/040908081541.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins