Featured Research

from universities, journals, and other organizations

Scientists Discover Way To Slow The Progression Of Prostate Cancer

Date:
September 9, 2004
Source:
Imperial College London
Summary:
A UK based team of scientists and doctors have found a way to slow the development and spread of prostate cancer by stopping certain genes from becoming active.

A UK based team of scientists and doctors have found a way to slow the development and spread of prostate cancer by stopping certain genes from becoming active.

According to research published online in Oncogene, the team from Imperial College London, Cancer Research UK and Hammersmith Hospital have found a way to stop the development of cancer cells in the lab by limiting the effects of the androgen hormone and the genes which are activated by it. They have developed a way to silence these genes using an androgen receptor (AR) repressor, delivered by gene therapy.

Androgen is a hormone which is responsible for male characteristics and the development and function of male sexual organs. Scientists know that AR is active in virtually all prostate cancers, and the gene from the AR is frequently mutated.

Professor Jonathan Waxman, from Imperial College London and Hammersmith Hospital, and one of the researchers, comments: "Currently prostate cancer patients receive hormone therapy which stops the androgen receptor from producing testosterone, but this new therapy could prove much more effective in stopping the development of cancer.

"By using this repressor we can stop the genes from becoming active, and hopefully limit the development of cancer. We hope to combine using this repressor with existing cancer treatments to help develop newer, more effective methods to treat cancer."

The androgen receptor plays a key role in the development and progression of cancer. Currently doctors use anti-androgens to stop the genes regulated by the androgen receptor from being switched on, but the team have now discovered a repressor called PZLF, which has been fused with the AR to produce PLZF-AF, a combination of the two.

Professor Waxman adds: "Although this could be very good news for prostate cancer patients, we do need to be careful in interpreting the results. As yet we have not carried out these tests in patients, and getting the right delivery system will be key to this becoming an effective treatment, potentially helping many thousands of people in the UK alone."

The research was supported by Charing Cross and Hammersmith Hospitals Trustees, the Prostate Cancer Charity, Cancer Research UK and the Association for International Cancer Research.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Scientists Discover Way To Slow The Progression Of Prostate Cancer." ScienceDaily. ScienceDaily, 9 September 2004. <www.sciencedaily.com/releases/2004/09/040908081541.htm>.
Imperial College London. (2004, September 9). Scientists Discover Way To Slow The Progression Of Prostate Cancer. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2004/09/040908081541.htm
Imperial College London. "Scientists Discover Way To Slow The Progression Of Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2004/09/040908081541.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins