Featured Research

from universities, journals, and other organizations

Scientists Begin Validation Study Of Test To Detect Recurrence Of Bladder Cancer

Date:
October 7, 2004
Source:
NIH/National Cancer Institute
Summary:
A three-year study to validate a test to detect the recurrence of bladder cancer has been initiated by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), at 12 centers across the United States and Canada.

A three-year study to validate a test to detect the recurrence of bladder cancer has been initiated by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), at 12 centers across the United States and Canada. This test was conceived and is being conducted by NCI’s Early Detection Research Network (EDRN). By examining genetic changes in DNA obtained through urine samples, the test, if successfully validated, will provide a sensitive and non-invasive method of screening for bladder cancer recurrence.

“This is the first study of its kind,” said Sudhir Srivastava, Ph.D., who heads EDRN as chief of the Cancer Biomarkers Research Group in NCI’s Division of Cancer Prevention. “It’s the first study testing a marker for bladder cancer, and the first Phase III study for an EDRN-created test.”

Bladder cancer, with over 60,000 estimated new cases this year, is both one of the more common cancers and one that has a high recurrence rate. Frequent surveillance of bladder cancer patients is critical, but current procedures have shortcomings. Urine cytology, which checks the number and appearance of cells in urine samples, often fails to detect early tumors. Cystoscopy — examining the urethra and bladder with a thin lighted scope — can give patients a false-positive result in addition to being invasive and unpleasant.

The new EDRN-created test looks to improve upon these weaknesses. EDRN, established by NCI in early 2000, is a broad, interdisciplinary consortium whose work is aimed at both identifying and validating cancer biomarkers for use in early cancer detection. Numerous proteins and genes have been linked with a variety of cancers, which can make them targets for therapy, as well as targets for identifying the risk of cancer onset, progression, or recurrence. The validation — proving that the link accurately signifies the risk for or presence of cancer — is the critical step to create a truly useful test.

The bladder cancer test uses a technology known as microsatellite DNA analysis (MSA). Microsatellites, also known as short tandem repeats, are repeating units of one to six nucleotides (e.g. CACACACA) found throughout human chromosomes. These repeating regions are frequently mutated in tumors, either through deletions or by an extension of the number of repeats. For screening for recurrent bladder cancer, DNA can be easily extracted from cells that are normally present in urine, and compared to DNA sequences of unaffected cells, such as lymphocytes, from the same patients. Early studies have shown this non-invasive analysis can have over 90 percent accuracy.

In the validation study, overseen by Jacob Kagan, Ph.D., program director of NCI’s Cancer Biomarkers Research Group, 15 different biomarkers in 300 patients diagnosed with bladder cancer will be examined in an effort to predict cancer recurrence. Individuals with healthy bladders and individuals with non-cancerous bladder problems that could be misdiagnosed as cancer, such as kidney stones or urinary tract infections, will be used as controls. The participating institutions will collect samples from patients in this study, and the samples will be analyzed by Commonwealth Biotechnologies Inc., located in Richmond, Va. “The primary goal of this study is to monitor MSA for bladder cancer recurrence,” said Srivastava, “but the longer goal is to also use the test for early detection of new bladder cancer occurrence.”

This trial will run for three years and final results are expected in September 2007. After Phase III validation, Cangen Biotechnologies Inc., which holds the license for this MSA test, plans to seek Food and Drug Administration approval for this test to make it publicly available. Additionally, EDRN is working on two other early detection tests involving examination of protein biomarkers in blood serum to detect early tumors of the prostate and liver.

For more information about the Early Detection Research Network (EDRN), visit the EDRN home page at http://www3.cancer.gov/prevention/cbrg/edrn.

For more information about cancer, visit the NCI Web site at http://www.cancer.gov or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).


Story Source:

The above story is based on materials provided by NIH/National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Cancer Institute. "Scientists Begin Validation Study Of Test To Detect Recurrence Of Bladder Cancer." ScienceDaily. ScienceDaily, 7 October 2004. <www.sciencedaily.com/releases/2004/10/041006081644.htm>.
NIH/National Cancer Institute. (2004, October 7). Scientists Begin Validation Study Of Test To Detect Recurrence Of Bladder Cancer. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2004/10/041006081644.htm
NIH/National Cancer Institute. "Scientists Begin Validation Study Of Test To Detect Recurrence Of Bladder Cancer." ScienceDaily. www.sciencedaily.com/releases/2004/10/041006081644.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins