Featured Research

from universities, journals, and other organizations

Drug May Hinder Recovery From Heart Attacks

Date:
November 18, 2004
Source:
University Of Alberta
Summary:
Some new generation COX-2 inhibitors may not allow heart attack patients to recover fully, research indicates. Researchers at the University of Alberta have discovered a basic cellular process the body uses to balance pH in cells--also critical to recovery following a heart attack--is compromised by certain novel COX-2 inhibitors.

Some new generation COX-2 inhibitors may not allow heart attack patients to recover fully, research indicates.

Researchers at the University of Alberta have discovered a basic cellular process the body uses to balance pH in cells--also critical to recovery following a heart attack--is compromised by certain novel COX-2 inhibitors.

Bicarbonate transporters, enzymes critical to maintaining this delicate balance of bicarbonate across the cell membrane, are potently inhibited from doing their work by some clinically used non-steroidal anti-inflammatory drugs such as celecoxib, the active ingredient in Celebrex.

Celecoxib is an effective anti-inflammatory drug because of its effects on the enzyme cyclooxygenase-2 (COX-2). The work from the Casey laboratory indicates that the reported side-effects of celecoxib may result from their unintended inhibition of the body's ability to move bicarbonate.

The work was headed up by principal researcher Joe Casey, a University of Alberta physiology professor.

Bicarbonate (HCO3-) is the primary pH buffer of our bodies and the primary waste product of cellular energy production. Movement of the base, HCO3-, into or out of a cell will alkalinize or acidify the cell. Our cells carefully control the concentration and movement of HCO3- across the plasma membrane by regulation of bicarbonate transport proteins (BT) that can rapidly catalyse the transmembrane movement of HCO3-. The focus of Dr. Casey's laboratory's research is to understand the processes of transmembrane HCO3- transport at the molecular and cellular levels.

The work will appear in the November 23 issue of Molecular Membrane Biology. Co-researchers included Patricio Morgan, a postdoctoral research fellow in the Casey Research Group, and Claudiu Supuran, of the University of Florence, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica,Sesto Fiorentino, Italy.

Dr. Casey's work is funded by the Canadian Institutes of Health Research and the Heart and Stroke Foundation. Dr. Casey is a Senior Scholar of the Alberta Heritage Foundation for Medical Research.


Story Source:

The above story is based on materials provided by University Of Alberta. Note: Materials may be edited for content and length.


Cite This Page:

University Of Alberta. "Drug May Hinder Recovery From Heart Attacks." ScienceDaily. ScienceDaily, 18 November 2004. <www.sciencedaily.com/releases/2004/11/041117002303.htm>.
University Of Alberta. (2004, November 18). Drug May Hinder Recovery From Heart Attacks. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2004/11/041117002303.htm
University Of Alberta. "Drug May Hinder Recovery From Heart Attacks." ScienceDaily. www.sciencedaily.com/releases/2004/11/041117002303.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins