Featured Research

from universities, journals, and other organizations

Research Studies Drug To Treat Brain Metastases

Date:
December 16, 2004
Source:
Northwestern University
Summary:
A Northwestern University cancer researcher is conducting a study that will compare the effects of whole brain radiation therapy with supplemental oxygen without or with EfaproxynTM (efaproxiral), an experimental radiation sensitizer, in participants with brain cancer originating from metastatic breast cancer.

CHICAGO --- A Northwestern University cancer researcher is conducting a study that will compare the effects of whole brain radiation therapy with supplemental oxygen without or with EfaproxynTM (efaproxiral), an experimental radiation sensitizer, in participants with brain cancer originating from metastatic breast cancer.

It is believed that efaproxiral may improve the improve the effectiveness of whole brain radiation therapy in brain metastases from breast cancer, according to Virginia Kaklamani, M.D., assistant professor of medicine in the division of hematology/oncology at the Northwestern University Feinberg School of Medicine.

Kaklamani is a researcher at The Robert H. Lurie Comprehensive Cancer Center of Northwestern University and a staff hematologist/oncologist at the Northwestern Medical Faculty Foundation and at Northwestern Memorial Hospital.

Results from an earlier study suggested that the addition of efaproxiral to whole brain radiation therapy doubled survival among patients with metastatic breast cancer and significantly improved their quality of life.

Brain metastases occur when tumors spread to the brain from the primary tumor site in another part of the body. Whole brain radiation therapy is used to relieve symptoms and prolong survival and is the standard of care for treating patients with brain metastases.

Breast cancer is the second most common cause of brain metastases after lung cancer, accounting for 14 to 20 percent of the total incidence of brain metastases.

Efaproxiral is the first synthetic small-molecule compound designed to “sensitize” oxygen-deprived areas of tumors prior to radiation therapy by facilitating release of oxygen from hemoglobin, the oxygen-carrying protein contained in red blood cells, and increasing the level of oxygen in tumors.

The presence of oxygen in tumors is an essential element for the effectiveness of radiation therapy in the treatment of cancer. By increasing tumor oxygenation at the time of treatment, efaproxiral may enhance the efficacy of standard radiation therapy. Unlike chemotherapies or other radiation sensitizers, efaproxiral does not have to cross the blood brain barrier or enter the tumor to be effective.

To qualify as a participant in this study, you must have brain metastases from breast cancer and not had any previous treatment for brain metastases, including brain surgery and any form of radiation to the brain. During study treatment, you may continue to receive all therapies except chemotherapy.

For information on the efaproxiral study, call 312-695-0320.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "Research Studies Drug To Treat Brain Metastases." ScienceDaily. ScienceDaily, 16 December 2004. <www.sciencedaily.com/releases/2004/12/041203094506.htm>.
Northwestern University. (2004, December 16). Research Studies Drug To Treat Brain Metastases. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2004/12/041203094506.htm
Northwestern University. "Research Studies Drug To Treat Brain Metastases." ScienceDaily. www.sciencedaily.com/releases/2004/12/041203094506.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins