Featured Research

from universities, journals, and other organizations

New Breast Cancer Study Shows Hormonal Therapy Not Enough

Date:
December 9, 2004
Source:
Loyola University Health System
Summary:
Many postmenopausal women with hormone-dependent breast cancer (requires estrogen and/or progesterone to grow) may be undertreated if they do not receive chemotherapy in addition to hormonal therapy after surgery, according to a Loyola University Health System, Maywood, Ill., study.

SAN ANTONIO -- Many postmenopausal women with hormone-dependent breast cancer (requires estrogen and/or progesterone to grow) may be undertreated if they do not receive chemotherapy in addition to hormonal therapy after surgery, according to a Loyola University Health System, Maywood, Ill., study.

Loyola's Dr. Kathy S. Albain presented the results of a 10-year follow-up of The Breast Cancer Intergroup of North America Trial 0100 at the late breaking session of the San Antonio Breast Cancer Symposium annual meeting here today.

"The research shows that, in many cases, tamoxifen or other hormonal therapy alone is not optimal," said principal investigator and first author Albain, professor, division of hematology/oncology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, Ill.

"Overall, chemotherapy helped stop the cancer from recurring in postmenopausal women with receptor-positive breast cancer that has spread to the lymph nodes," said Albain. "This survival advantage was greatest when tamoxifen followed chemotherapy, rather than given concurrently.

"Ten-year disease-free-survival estimates were 48 percent for those treated with tamoxifen alone; 53 percent for concurrent chemohormonal therapy; and 60 percent for sequential therapy," said Albain, director, Breast Research Program; co-director of the multidisciplinary Breast Oncology Center; and director of the Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Health System, Maywood, Ill.

Albain and colleagues conducted a 10-year follow-up of 1,477 patients. A total of 550 patients received concurrent chemohormonal therapy (CAFT) (cyclophosphamide, doxorubicin, 5-fluorouracil, tamoxifen); another 566 patients received sequential chemohormonal therapy (CAF-T); and 361 patients received tamoxifen alone.

"Long-term follow-up of this large North American trial confirms that chemotherapy benefits postmenopausal women with hormone-dependent breast cancer," said Albain. "We discovered that women with very high levels of estrogen receptor in their tumors can probably avoid chemotherapy, but those with lower or intermediate levels benefit from it over and above tamoxifen.

A second aspect of this study explored the use of various molecular markers measured on the breast tumor to predict the added value of chemotherapy. The purpose of this was to determine if the individual's biologic profile on an individual tumor enables us to tailor therapy more specifically.

"These results will help current breast cancer treatment in that we are moving to regimens tailored to the specific individual's cancer and it will stimulate future research," said Albain.

Co-authors of the study are K. S. Albain; W. Barlow; F. O'Malley; K Siziopikou; I-T Yeh; P. Ravdin; D. Lew; W. Farrar; G. Burton; S. Ketchel; C. Cobau; E. Levine; J. Ingle; K. Pritchard; A. Lichter; D. Schneider; M. Abeloff; I. C. Henderson; L. Norton; D. Hayes; S. Green; R. Livingston; S. Martino; C. K. Osborne; and D. C. Allred, The Breast Cancer Intergroup of North America, Loyola University Chicago Stritch School of Medicine, Maywood, Ill.

For more information on Loyola University Health System, log onto http://www.luhs.org

The 27th Annual San Antonio Breast Cancer Symposium meeting at the Henry B. Gonzalez Convention Center, San Antonio, Tex., runs through December 11, 2004.


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Cite This Page:

Loyola University Health System. "New Breast Cancer Study Shows Hormonal Therapy Not Enough." ScienceDaily. ScienceDaily, 9 December 2004. <www.sciencedaily.com/releases/2004/12/041208234619.htm>.
Loyola University Health System. (2004, December 9). New Breast Cancer Study Shows Hormonal Therapy Not Enough. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2004/12/041208234619.htm
Loyola University Health System. "New Breast Cancer Study Shows Hormonal Therapy Not Enough." ScienceDaily. www.sciencedaily.com/releases/2004/12/041208234619.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins