Featured Research

from universities, journals, and other organizations

Discovery Of Compound Could Enhance Cancer Treatments With Fewer Side Effects

Date:
December 24, 2004
Source:
Michigan State University
Summary:
The discovery of a new compound by Michigan State University researchers could lead to improved chemotherapy treatments for different types of cancers – potentially with fewer side effects.

EAST LANSING, Mich. – The discovery of a new compound by Michigan State University researchers could lead to improved chemotherapy treatments for different types of cancers – potentially with fewer side effects.

Related Articles


The discovery of the compound – known as SP-4-84 – was made by an MSU team led by Jetze Tepe, an assistant professor of chemistry, and is detailed in the December issue of the journal Chemistry & Biology.

The researchers believe that the compound, when used in conjunction with chemotherapy drugs such as cisplatin and camptothecin, can make the anti-cancer drugs much more effective.

“This may potentially mean that one could use less than one-tenth of the current drug dosage and still get the same therapeutic results – but fewer side effects – or use the same drug dosage which is now much more effective in its treatment,” Tepe said.

Even though this new compound is in the earliest stage of development, this is potentially good news for the millions of Americans diagnosed with cancer every year. The national Centers for Disease Control and Prevention says more than a half-million Americans die of cancer every year, second only to heart disease.

Here is how the newly discovered compound works: Most anti-cancer drugs work by causing cell damage, such as DNA damage, which ultimately kills the cancer cells. However, cancer cells are also prone to repair themselves and survive the damage done by drugs, which renders the drugs less effective.

Tepe and his colleagues found that when SP-4-84 was added to certain anti-cancer drugs, it inhibited the cancer cell’s ability to survive chemotherapeutic treatment.

“Essentially,” he said, “it sensitizes only cancer cells to chemotherapeutics by blocking the cancer cell’s ability to survive the damage that was caused by the chemotherapeutic drugs.”

Another problem with chemotherapy drugs is that they generally don’t discriminate between cancer cells and healthy cells. The drugs basically damage all cells that are continuing to replicate.

“So, if we’re able to give the patient a drug that remains as effective despite a smaller dose, this could spare the patient a lot of side effects such as severe nausea, kidney or liver damage, and other side effects typically experienced during chemotherapy,” Tepe said.

“Tests preformed with cancer cells in culture found that over a 48-hour period small amounts of SP-4-84 made camptothecin 75 times more effective that conventional treatment,” he said. “However, when we used the compound on non-cancerous cells, there was absolutely no effect. It appears right now that the compound is only selective for cancer cells.”

Thus far, SP-4-84 appears to be extremely non-toxic, he said.

In their current work, Tepe and his co-workers have teamed up with MSU’s Carcinogenesis Laboratory, where the teams are evaluating the new compound in mice.

“As with all new discoveries, much more work needs to be done to evaluate the potential of this compound for its ability to improve conventional therapeutic treatment,” Tepe said.

Other members of Tepe’s team include graduate students Vasudha Sharma and Satyamaheshwar Peddibhotla, and research associate Theresa Lansdell.


Story Source:

The above story is based on materials provided by Michigan State University. Note: Materials may be edited for content and length.


Cite This Page:

Michigan State University. "Discovery Of Compound Could Enhance Cancer Treatments With Fewer Side Effects." ScienceDaily. ScienceDaily, 24 December 2004. <www.sciencedaily.com/releases/2004/12/041219134846.htm>.
Michigan State University. (2004, December 24). Discovery Of Compound Could Enhance Cancer Treatments With Fewer Side Effects. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2004/12/041219134846.htm
Michigan State University. "Discovery Of Compound Could Enhance Cancer Treatments With Fewer Side Effects." ScienceDaily. www.sciencedaily.com/releases/2004/12/041219134846.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rehab Robot Helps Restore Damaged Muscles and Nerves

Rehab Robot Helps Restore Damaged Muscles and Nerves

Reuters - Innovations Video Online (Mar. 1, 2015) A rehabilitation robot prototype to help restore deteriorated nerves and muscles using electromyography and computer games. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins